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Maintenance of skeletal muscle mass during FOLFIRINOX is a favorable prognostic factor in pancreatic cancer patients

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Author(s)
Dong Woo ShinMinseok Albert KimJong-chan LeeJaihwan KimJin-Hyeok Hwang
Keimyung Author(s)
Shin, Dong Woo
Department
Dept. of Internal Medicine (내과학)
Journal Title
BMC Res Notes
Issued Date
2021
Volume
14
Issue
1
Keyword
Locally advanced pancreatic cancerSkeletal muscleAdipose tissuePrognosisFOLFIRINOX
Abstract
Objective:
The study aimed to investigate the effect of body composition changes during chemotherapy on clinical outcomes in patients with pancreatic cancer.

Results:
In patients with locally advanced pancreatic cancer (LAPC), the cross-sectional area of skeletal muscle (SM) and adipose tissue (AT) at the level of third lumbar vertebra was measured. The SM and AT ratios indicated the changes during chemotherapy. The patients were classified into three groups based on these ratios: group 1, ≥ 1.00; group 2, 0.85–0.99; group 3, < 0.85. The overall survival (OS) and surgical resection rates were estimated. Fifty-eight patients with LAPC who received first-line FOLFIRINOX were analyzed. Fifteen (25.9%) patients who underwent resection showed maintained BMI, SM, and AT as compared to the patients who did not undergo resection. As the SM ratio decreased, the risk for death increased significantly. Further, the resection rate was significantly higher in patients with maintained SM compared to those with low SM ratio. On the contrary, the change in AT ratio was not associated with OS and resection rate; however, significant decrease in AT more than 15% showed poor clinical outcomes. Maintenance of SM during chemotherapy is a reliable prognostic factor indicating longer OS and higher resection rate.
Keimyung Author(s)(Kor)
신동우
Publisher
School of Medicine (의과대학)
Citation
Dong Woo Shin et al. (2021). Maintenance of skeletal muscle mass during FOLFIRINOX is a favorable prognostic factor in pancreatic cancer patients. BMC Res Notes, 14(1), 272. doi: 10.1186/s13104-021-05681-x
Type
Article
ISSN
1756-0500
Source
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-021-05681-x
DOI
10.1186/s13104-021-05681-x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43931
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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