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Serum Peptide Immunoglobulin G Autoantibody Response in Patients with Different Central Nervous System Inflammatory Demyelinating Disorders

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Author(s)
Hye Lim LeeJin-Woo ParkJin Myoung SeokMi Young JeonHojin KimYoung-Min LimHa Young ShinSa-Yoon KangOh-Hyun KwonSang-Soo LeeHung Youl SeokJu-Hong MinSung-Hyun LeeByung-Jo KimByoung Joon Kim
Keimyung Author(s)
Seok, Hung Youl
Department
Dept. of Neurology (신경과학)
Journal Title
Diagnostics (Basel)
Issued Date
2021
Volume
11
Issue
8
Keyword
CNS inflammatory demyelinating disorderpeptide microarrayIgG response
Abstract
Previous efforts to discover new surrogate markers for the central nervous system (CNS) inflammatory demyelinating disorders have shown inconsistent results; moreover, supporting evidence is scarce. The present study investigated the IgG autoantibody responses to various viral and autoantibodies-related peptides proposed to be related to CNS inflammatory demyelinating disorders using the peptide microarray method. We customized a peptide microarray containing more than 2440 immobilized peptides representing human and viral autoantigens. Using this, we tested the sera of patients with neuromyelitis optica spectrum disorders (NMOSD seropositive, n = 6; NMOSD seronegative, n = 5), multiple sclerosis (MS, n = 5), and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD, n = 6), as well as healthy controls (HC, n = 5) and compared various peptide immunoglobulin G (IgG) responses between the groups. Among the statistically significant peptides based on the pairwise comparisons of IgG responses in each disease group to HC, cytomegalovirus (CMV)-related peptides were most clearly distinguishable among the study groups. In particular, the most significant differences in IgG response were observed for HC vs. MS and HC vs. seronegative NMOSD (p = 0.064). Relatively higher IgG responses to CMV-related peptides were observed in patients with MS and NMOSD based on analysis of the customized peptide microarray.
Keimyung Author(s)(Kor)
석흥열
Publisher
School of Medicine (의과대학)
Citation
Hye Lim Lee et al. (2021). Serum Peptide Immunoglobulin G Autoantibody Response in Patients with Different Central Nervous System Inflammatory Demyelinating Disorders. Diagnostics (Basel), 11(8), 1339. doi: 10.3390/diagnostics11081339
Type
Article
ISSN
2075-4418
Source
https://www.mdpi.com/2075-4418/11/8/1339
DOI
10.3390/diagnostics11081339
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43937
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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