계명대학교 의학도서관 Repository

Atrial fibrillation and kidney function: a bidirectional Mendelian randomization study

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Author(s)
Sehoon ParkSoojin LeeYaerim KimYeonhee LeeMin Woo KangKwangsoo KimYong Chul KimSeung Seok HanHajeong LeeJung Pyo LeeKwon Wook JooChun Soo LimYon Su KimDong Ki Kim
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
Eur Heart J
Issued Date
2021
Volume
42
Issue
29
Keyword
Atrial fibrillationChronic kidney diseaseMendelian randomizationEstimated glomerular filtration rate
Abstract
Aims:
The aim of this study was to investigate the causal effects between atrial fibrillation (AF) and kidney function.

Methods and results:
We performed a bidirectional summary-level Mendelian randomization (MR) analysis implementing the results from a large-scale genome-wide association study for estimated glomerular filtration rate (eGFR) by the CKDGen (N = 765 348) and AF (N = 588 190) to identify genetic instruments. The inverse variance weighted method was the main MR method used. For replication, an allele score-based MR was performed by individual-level data within a UK Biobank cohort of white British ancestry individuals (N = 337 138). A genetic predisposition to AF was significantly associated with decreased eGFR [for log-eGFR, beta −0.003 (standard error, 0.0005), P < 0.001] and increased risk of chronic kidney disease [beta 0.059 (0.0126), P < 0.001]. The significance remained in MR sensitivity analyses and the causal estimates were consistent when we limited the analysis to individuals of European ancestry. Genetically predicted eGFR did not show a significant association with the risk of AF [beta −0.366 (0.275), P = 0.183]. The results were similar in allele score-based MR, as allele score for AF was significantly associated with reduced eGFR [for continuous eGFR, beta −0.079 (0.021), P < 0.001], but allele score for eGFR did not show a significant association with risk of AF [beta −0.005 (0.008), P = 0.530].

Conclusions:
Our study supports that AF is a causal risk factor for kidney function impairment. However, an effect of kidney function on AF was not identified in this study.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Citation
Sehoon Park et al. (2021). Atrial fibrillation and kidney function: a bidirectional Mendelian randomization study. Eur Heart J, 42(29), 2816–2823. doi: 10.1093/eurheartj/ehab291
Type
Article
ISSN
1522-9645
Source
https://academic.oup.com/eurheartj/article/42/29/2816/6282432
DOI
10.1093/eurheartj/ehab291
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43940
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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