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Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019

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Author(s)
Ki Wook YunKyuyol RhieJin Han KangKyung-Hyo KimJong Gyun AhnYae-Jean KimByung Wook EunSung Hee OhHye-Kyung ChoYoung Jin HongNam Hee KimYun-Kyung KimHyunju LeeTaekjin LeeHwang Min KimEun Young ChoChun Soo KimSu Eun ParkChi Eun OhDae Sun JoEun Song SongJina LeeJae Hong ChoiJoon Kee LeeHoan Jong LeeEun Hwa Choi
Keimyung Author(s)
Kim, Chun Soo
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Vaccine
Issued Date
2021
Volume
39
Issue
40
Keyword
Streptococcus pneumoniaeSerotypeGenotypeChildren
Abstract
Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014–2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 ( p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.
Keimyung Author(s)(Kor)
김천수
Publisher
School of Medicine (의과대학)
Citation
Ki Wook Yun et al. (2021). Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019. Vaccine, 39(40), 5787–5793. doi: 10.1016/j.vaccine.2021.08.072
Type
Article
ISSN
0264-410X
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0264410X21011208
DOI
10.1016/j.vaccine.2021.08.072
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43986
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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