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Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: a Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group

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Author(s)
Kyung Mi ParkKeon Hee YooSeong Koo KimJae Wook LeeNack-Gyun ChungHee Young JuHong Hoe KooChul Joo LyuSeung Min HanJung Woo HanJung Yoon ChoiKyung Taek HongHyoung Jin KangHee Young ShinHo Joon ImKyung-Nam KohHyery KimHoon KookHee Jo BaekBo Ram KimEu Jeen YangJae Young LimEun Sil ParkEun Jin ChoiSang Kyu ParkJae Min LeeYe Jee ShimJi Yoon KimJi Kyoung ParkSeom Kim KongYoung Bae ChoiBin ChoYoung Tak Lim
Keimyung Author(s)
Shim, Ye Jee
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Cancer Res Treat
Issued Date
2022
Volume
54
Issue
1
Keyword
Acute promyelocytic leukemiaAll-trans retinoic acidChildhood
Abstract
Purpose:
Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea.

Materials and Methods:
Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively.

Results:
Of 801 acute myeloid leukemia(AML) children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3-18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had WBC count greater than 10x109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid (ATRA) and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 (86.8%) patients achieved complete remission (CR) after induction chemotherapy. The causes of death were 3 intracranial hemorrhage (ICH), 1 cerebral infarction, and 1 sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival rate (EFS) and overall survival rates (OS) were 82.1 ± 4.4%, 89.7 ± 5.1% respectively. The 4-yr OS was significantly higher in patients with initial WBC <10x109/L than in those with initial WBC ≥10x109/L (p=0.02).

Conclusion:
This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.
Keimyung Author(s)(Kor)
심예지
Publisher
School of Medicine (의과대학)
Citation
Kyung Mi Park et al. (2022). Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: a Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group. Cancer Res Treat, 54(1), 269–276. doi: 10.4143/crt.2021.313
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2021.313
DOI
10.4143/crt.2021.313
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43995
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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