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Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas

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Author(s)
Su Jung KumHye Won LeeSoon Gu KimHyungsik ParkIlseon HwangSang Pyo Kim
Keimyung Author(s)
Lee, Hye WonHwang, Il SeonKim, Sang Pyo
Department
Dept. of Pathology (병리학)
Journal Title
J Pathol Transl Med
Issued Date
2022
Volume
56
Issue
1
Keyword
Non-functioning pituitary adenomasPituitary tumor transforming gene expressionInvasiveness
Abstract
Background:
Pituitary tumor transforming gene 1 (PTTG1), paired-like homeodomain 2 (PITX2), and galectin-3 have been widely studied as predictive biomarkers for various tumors and are involved in tumorigenesis and tumor progression. We evaluated the usefulness of PTTG1, PITX2, and galectin-3 as predictive biomarkers for invasive non-functioning pituitary adenomas (NFPAs) by determining the relationship between the expressions of these three proteins and the invasiveness of the NFPAs. We also investigated whether PTTG1, E-cadherin, and Ki-67, which are known to be related to each other, show a correlation with NFPA features.

Methods:
A retrospective study was conducted on 87 patients with NPFAs who underwent surgical removal. The NFPAs were classified into three groups based on magnetic resonance imaging findings of suprasellar extension and cavernous sinus invasion. Immunohistochemical staining for PTTG1, PITX2, galectin-3, E-cadherin, and Ki-67 was performed on tissue microarrays.

Results:
PTTG1 expression showed a statistically significant correlation with the invasiveness of NFPAs, whereas PITX2 and galectin-3 did not have a relationship with the invasiveness of NFPAs. Moreover, there was no association among PTTG1, E-cadherin, and Ki-67 expression.

Conclusions:
PTTG1 has the potential to serve as a predictive biomarker for invasive NFPA. Furthermore, this study may serve as a reference for the development of PTTG1-targeted therapeutic agents.
Keimyung Author(s)(Kor)
이혜원
황일선
김상표
Publisher
School of Medicine (의과대학)
Citation
Su Jung Kum et al. (2022). Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas. J Pathol Transl Med, 56(1), 22–31. doi: 10.4132/jptm.2021.08.31
Type
Article
ISSN
2383-7845
Source
https://www.jpatholtm.org/journal/view.php?number=16996
DOI
10.4132/jptm.2021.08.31
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44008
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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