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The FGFR Family Inhibitor AZD4547 Exerts an Antitumor Effect in Ovarian Cancer Cells

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Author(s)
Yu Ran NaJin Young KimChang Ho SongMikyung KimYen Thi DoTam Thuy Lu VoEunsom ChoiEunyoung HaJi Hae SeoSo-Jin Shin
Keimyung Author(s)
Kim, Jin YoungHa, Eun YoungSeo, Ji HyeShin, So Jin
Department
Dept. of Internal Medicine (내과학)
Dept. of Biochemistry (생화학)
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Int J Mol Sci
Issued Date
2021
Volume
22
Issue
19
Keyword
AZD4547cancer stem cellsfibroblast growth factorfibroblast growth factor receptorovarian cancer
Abstract
The dysregulation of fibroblast growth factor (FGF) signaling has been implicated in tumorigenesis, tumor progression, angiogenesis, and chemoresistance. The small-molecule AZD4547 is a potent inhibitor of FGF receptors. This study was performed to investigate the antitumor effects and determine the mechanistic details of AZD4547 in ovarian cancer cells. AZD4547 markedly inhibited the proliferation and increased the apoptosis of ovarian cancer cells. AZD4547 also suppressed the migration and invasion of ovarian cancer cells under nontoxic conditions. Furthermore, it attenuated the formation of spheroids and the self-renewal capacities of ovarian cancer stem cells and exerted an antiangiogenic effect. It also suppressed in vivo tumor growth in mice. Collectively, this study demonstrated the antitumor effect of AZD4547 in ovarian cancer cells and suggests that it is a promising agent for ovarian cancer therapy.
Keimyung Author(s)(Kor)
김진영
하은영
서지혜
신소진
Publisher
School of Medicine (의과대학)
Citation
Yu Ran Na et al. (2021). The FGFR Family Inhibitor AZD4547 Exerts an Antitumor Effect in Ovarian Cancer Cells. Int J Mol Sci, 22(19), 10817. doi: 10.3390/ijms221910817
Type
Article
ISSN
1422-0067
Source
https://www.mdpi.com/1422-0067/22/19/10817
DOI
10.3390/ijms221910817
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44031
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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