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Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS)

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Author(s)
Soo Jin LeeYoung Suk ParkYong-Jin KimSang-Uk HanGeum-Sook HwangYeyoung HanYoonseok HeoEunyoung HaTae Kyung Ha
Keimyung Author(s)
Ha, Eun Young
Department
Dept. of Biochemistry (생화학)
Journal Title
J Clin Med
Issued Date
2021
Volume
10
Issue
21
Keyword
trimethylamine N-oxidecardiovascular diseaseobesitybariatric surgerydiabetes mellitus
Abstract
Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite, has been implicated as a novel risk factor for cardiovascular events related to obesity and type 2 diabetes mellitus (T2DM). The aim of the study was to test the hypothesis if TMAO is associated with the reduction of cardiovascular disease in the Korean obese patients who underwent bariatric surgery. From a subgroup of a multicenter, nonrandomized, controlled trial, titled KOBESS, 38 obese patients, 18 with and 20 without T2DM, who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were investigated. Bariatric surgery is indicated for Korean patients with a body mass index (BMI) ≥ 35 kg/m2 or for Korean patients with a BMI ≥ 30 kg/m2 who have comorbidities. Serum levels of TMAO and its precursors, betaine, carnitine, and choline were measured before and six months after bariatric surgery. The levels of TMAO and its precursors did not differ between obese patients with T2DM and non-T2DM at baseline. However, TMAO increased more than twofold in patients with T2DM after RYGB surgery, but not in patients without T2DM. Choline levels were decreased by half in all patients after RYGB. In patients with T2DM who underwent SG, TMAO, betaine, and carnitine levels did not change after the surgery. Furthermore, in obese patients who underwent bariatric surgery, increased TMAO levels were associated with both T2DM and RYGB, while reduced choline levels were associated with RYGB. These associations need to be further elucidated in follow-up studies to gain further insights into the relationship between TMAO levels and bariatric surgery outcomes.
Keimyung Author(s)(Kor)
하은영
Publisher
School of Medicine (의과대학)
Citation
Soo Jin Lee et al. (2021). Changes in Trimethylamine-N-oxide Levels in Obese Patients following Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy in a Korean Obesity Surgical Treatment Study (KOBESS). J Clin Med, 10(21), 5091. doi: 10.3390/jcm10215091
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/10/21/5091
DOI
10.3390/jcm10215091
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44040
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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