계명대학교 의학도서관 Repository

Association between early post-transplant hypertension or related antihypertensive use and prognosis of kidney transplant recipients: a nationwide observational study

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Author(s)
Sehoon ParkSung Jin KangJang Wook LeeJi Eun KimYaerim KimKwangsoo KimMinsu ParkYong Chul KimYon Su KimYaeji LimHajeong Lee
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Nephrol
Issued Date
2021
Volume
34
Keyword
TransplantationHypertensionCardiovascular disease
Abstract
Background:
Additional research is warranted for the clinical significance of post-transplant hypertension and related antihypertensive medication use in kidney transplant (KT) recipients.

Methods:
This observational study included nationwide KT recipients who maintained a functioning graft for at least 1 year after KT in South Korea, observed between 2008 and 2017. The use of antihypertensive medications lasting between 6 months and 1 year was the main exposure, and those who had inconsistent/transient use of antihypertensive drugs were excluded. The prognostic outcome included death-censored graft failure (DCGF), death-with functioning graft (DWFG), and major adverse cerebrocardiovascular events (MACCEs).

Results:
We included 8,014 patients without post-transplant hypertension and 6,114 recipients who received treatment for hypertension in the post-transplant period. Those with post-transplant hypertension had a significantly higher risk of DCGF than those without [adjusted hazard ratio (HR) 1.27 (1.09–1.48)]. Post-transplant hypertension patients who required multiple drugs showed a significantly higher risk of DWFG [HR 1.57 (1.17–2.10)] and MACCE [HR 1.35 (1.01–1.81)] than the controls. Among the single-agent users, those who received beta-blockers showed a significantly higher risk of DCGF, although the risks of DWFG or MACCE were similar between the types of antihypertensive agents. Among the multiple agent users, the prognosis was similar, regardless of the prescribed types of antihypertensive agents.

Conclusion:
Post-transplant hypertension was associated with poor post-transplant prognosis, particularly when multiple types of medications were required for treatment. During initial prescription of antihypertensive medication, clinicians may consider that beta-blockers were associated with a higher risk of DCGF in the single-agent users.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Citation
Sehoon Park et al. (2021). Association between early post-transplant hypertension or related antihypertensive use and prognosis of kidney transplant recipients: a nationwide observational study. J Nephrol, 34, 1457–1465. doi: 10.1007/s40620-021-01143-6
Type
Article
ISSN
1724-6059
Source
https://link.springer.com/article/10.1007/s40620-021-01143-6
DOI
10.1007/s40620-021-01143-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44042
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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