계명대학교 의학도서관 Repository

Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates

Metadata Downloads
Author(s)
Sungwon JeonAsta BlazyteChanghan YoonHyojung RyuYeonsu JeonYoungjune BhakDan BolserAndrea ManicaEun-Seok ShinYun Sung ChoByung Chul KimNamhee RyooHansol ChoiJong Bhak
Keimyung Author(s)
Ryoo, Nam Hee
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Mol Cells
Issued Date
2021
Volume
44
Issue
9
Keyword
allele frequencycase fatality rateCOVID-19SARS-CoV-2TMPRSS2
Abstract
Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones. One potential explanation for this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene, a key enzyme essential for viral infection and found a significant association between the COVID-19 case fatality rate and the V197M allele frequencies, using over 200,000 present-day and ancient genomic samples. East Asian countries have higher V197M allele frequencies than other regions, including European countries which correlates to their lower case fatality rates. Structural and energy calculation analysis of the V197M amino acid change showed that it destabilizes the TMPRSS2 protein, possibly negatively affecting its ACE2 and viral spike protein processing.
Keimyung Author(s)(Kor)
류남희
Publisher
School of Medicine (의과대학)
Citation
Sungwon Jeon et al. (2021). Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates. Mol Cells, 44(9), 680–687. doi: 10.14348/molcells.2021.2249
Type
Article
ISSN
0219-1032
Source
https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.2249
DOI
10.14348/molcells.2021.2249
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44054
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.