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Novel Three-Dimensional Knitted Fabric for Pressure Ulcer Prevention: Preliminary Clinical Application and Testing in a Diabetic Mouse Model of Pressure Ulcers

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Author(s)
Sungae KimJamin HongYongseong LeeDaegu Son
Keimyung Author(s)
Kim, Sung AeSon, Dae Gu
Department
Dept. of Dermatology (피부과학)
Dept. of Plastic Surgery (성형외과학)
Journal Title
Arch Plast Surg
Issued Date
2022
Volume
49
Issue
2
Keyword
diabetes complicationspressure ulcerstreptozotocinpolyesters
Abstract
Background:
Population aging has led to an increased incidence of pressure ulcers, resulting in a social burden and economic costs. We developed a three-dimensional knitted fabric (3-DKF) with a pressure-reducing function that can be applied topically in the early stages of pressure ulcers to prevent progression.

Methods:
We evaluated the effects of the 3-DKF in a streptozotocin-induced diabetes mellitus pressure ulcer mouse model, and the fabric was preliminarily applied to patients. Twelve-week-old male C57BL/6 mice were used for the animal experiments. In the pressure ulcer mouse model, an ischemia-reperfusion injury was created using a magnet on the dorsa of the mice. Pressure was measured with BodiTrak before and after applying the 3-DKF to 14 patients at risk of sacral pressure ulcers.

Results:
In the 3-DKF-applied mice group, the ulcers were shallower and smaller than those in the control group. Compared with the mice in the control group, the 3-DKF group had lower platelet-derived growth factor-α and neutrophil elastase expression, as parameters related to inflammation, and increased levels of transforming growth factor (TGF)-β1, TGF-β3, proliferating cell nuclear antigen, and α-smooth muscle actin, which are related to growth factors and proliferation. Additionally, typical normal tissue staining patterns were observed in the 3-DKF group. In the preliminary clinical analysis, the average skin pressure was 26.2 mm Hg before applying the 3-DKF, but it decreased to an average of 23.4 mm Hg after 3-DKF application.

Conclusion:
This study demonstrated that the newly developed 3-DKF was effective in preventing pressure ulcers through testing in a pressure ulcer animal model and preliminary clinical application.
Keimyung Author(s)(Kor)
김성애
손대구
Publisher
School of Medicine (의과대학)
Citation
Sungae Kim et al. (2022). Novel Three-Dimensional Knitted Fabric for Pressure Ulcer Prevention: Preliminary Clinical Application and Testing in a Diabetic Mouse Model of Pressure Ulcers. Arch Plast Surg, 49(2), 275–284. doi: 10.1055/s-0042-1744427
Type
Article
ISSN
2234-6171
Source
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0042-1744427
DOI
10.1055/s-0042-1744427
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44074
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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