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Nationwide Survey for Current Status of Laboratory Diagnosis of Clostridioides difficile Infection in Korea

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Author(s)
Hae-Sun ChungJeong Su ParkBo-Moon ShinHyeon Mi YooHeejung KimJihyun ChoChae Hoon LeeNam Hee RyooJae-Seok KimJae-Woo ChungKi Ho HongYou Sun KimYoung-Seok Cho
Keimyung Author(s)
Ryoo, Nam Hee
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
J Korean Med Sci
Issued Date
2022
Volume
37
Issue
5
Keyword
Clostridioides difficile InfectionLaboratory DiagnosisToxin AB Enzyme ImmunoassayNucleic Acid Amplification TestCultureGlutamate DehydrogenaseSurvey
Abstract
Background:
The interest in Clostridioides difficile infection (CDI) has increased, and the choice of assays became wider since the first national survey in Korea on CDI diagnosis in 2015. We conducted a survey of the domestic CDI assays with more varied questions to understand the current situation in Korea.

Methods:
In April 2018, about 50 questions on the current status of CDI assays and details on implementation and perceptions were written, and a survey questionnaire was administered to laboratory medicine specialists in 200 institutions.

Results:
One-hundred and fifty institutions responded to the questionnaire, of which 90 (60.0%) including one commercial laboratory, performed CDI assays. The toxin AB enzyme immunoassay (toxin AB EIA), nucleic acid amplification test (NAAT), and C. difficile culture, glutamate dehydrogenase assay, alone or in combination with other assays, were used in 75 (84.3%), 52 (58.4%), 35 (36.0%), and 23 (25.8%), respectively, and 65 (73.0%) institutions performed a combination of two or more assays. The sensitivity of toxin AB EIA was more negatively perceived, and that on specificity was more positively perceived. The perception of sensitivity and specificity of NAAT was mostly positive. Perception on the algorithm test projected it as useful but in need of countermeasures. Sixty-three (73.3%) institutions responded that they performed surveillance on CDI.

Conclusion:
This study provides useful evidence on the current status of CDI laboratory diagnosis in Korea as well as on items that require improvement and is thought to aid in standardizing and improving the CDI laboratory diagnosis in Korea.
Keimyung Author(s)(Kor)
류남희
Publisher
School of Medicine (의과대학)
Citation
Hae-Sun Chung et al. (2022). Nationwide Survey for Current Status of Laboratory Diagnosis of Clostridioides difficile Infection in Korea. J Korean Med Sci, 37(5), e38. doi: 10.3346/jkms.2022.37.e38
Type
Article
ISSN
1598-6357
Source
https://jkms.org/search.php?where=aview&id=10.3346/jkms.2022.37.e38&code=0063JKMS&vmode=FULL
DOI
10.3346/jkms.2022.37.e38
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44083
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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