계명대학교 의학도서관 Repository

Long-term risk of all-cause mortality in live kidney donors: a matched cohort study

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Author(s)
Eunjeong KangSehoon ParkJina ParkYaerim KimMinsu ParkKwangsoo KimHyo Jeong KimMiyeun HanJang-Hee ChoJung Pyo LeeSik LeeSoo Wan KimSang Min ParkDong-Wan ChaeHo Jun ChinYong Chul KimYon Su KimInsun ChoiHajeong Lee
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
Kidney Res Clin Pract
Issued Date
2022
Volume
41
Issue
1
Keyword
End-stage kidney diseaseLiving donorsMortalityRisk assessmentPrognosis
Abstract
Background:
Long-term outcomes of live kidney donors remain controversial, although this information is crucial for selecting potential donors. Thus, this study compared the long-term risk of all-cause mortality between live kidney donors and healthy control.

Methods:
We performed a retrospective cohort study including donors from seven tertiary hospitals in South Korea. Persons who underwent voluntary health screening were included as controls. We created a matched control group considering age, sex, era, body mass index, baseline hypertension, diabetes, estimated glomerular filtration rate, and dipstick albuminuria. The study outcome was progression to end-stage kidney disease (ESKD), and all-cause mortality as identified in the linked claims database.

Results:
We screened 1,878 kidney donors and 78,115 health screening examinees from 2003 to 2016. After matching, 1,701 persons remained in each group. The median age of the matched study subjects was 44 years, and 46.6% were male. Among the study subjects, 2.7% and 16.6% had underlying diabetes and hypertension, respectively. There were no ESKD events in the matched donor and control groups. There were 24 (1.4%) and 12 mortality cases (0.7%) in the matched donor and control groups, respectively. In the age-sex adjusted model, the risk for all-cause mortality was significantly higher in the donor group than in the control group. However, the significance was not retained after socioeconomic status was included as a covariate (adjusted hazard ratio, 1.82; 95% confidence interval, 0.87-3.80).

Conclusion:
All-cause mortality was similar in live kidney donors and matched non-donor healthy controls with similar health status and socioeconomic status in the Korean population.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Citation
Eunjeong Kang et al. (2022). Long-term risk of all-cause mortality in live kidney donors: a matched cohort study. Kidney Res Clin Pract, 41(1), 102–113. doi: 10.23876/j.krcp.21.042
Type
Article
ISSN
2211-9140
Source
https://www.krcp-ksn.org/journal/view.php?number=6079
DOI
10.23876/j.krcp.21.042
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44088
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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