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허혈뇌졸중에서 비타민 K 비의존경구항응고제의 사용

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Author(s)
Hyungjong ParkJoonsang Yoo
Keimyung Author(s)
Park, Hyung Jong
Department
Dept. of Neurology (신경과학)
Journal Title
대한신경과학회지
Issued Date
2022
Volume
40
Issue
1
Keyword
Ischemic strokeAnticoagulantsDabigatranRivaroxabanApixabanEdoxaban
Abstract
Atrial fibrillation (AF) is associated with an increased incidence of ischemic stroke and transient ischemic attack. A confluence of various factors such as blood stasis, endothelial dysfunction, and prothrombotic state could be contributing to the thrombogenesis in AF. Anticoagulation is the first-line therapy for the prevention of thromboembolism by AF. In current days, non-vitamin K dependent oral anticoagulants (NOAC) are considered as the preferred choice of anticoagulants to prevent ischemic stroke in patients with AF. NOACs have comparable good efficacy and better safety with a predictable anticoagulant effect without the routine coagulation monitoring compared to vitamin K dependent oral anticoagulant. However, the proper use of NOACs needs a careful approach to many practical aspects for balancing the preventing thromboembolic events and bleeding risk. Thus, understanding the drug metabolism and indication of NOAC for a specific situation is essential. In this article, we review major clinical trials, the mechanism, and the use of NOACs in the actual clinical setting of managing ischemic stroke patients.
Alternative Title
Use of Non-Vitamin K Dependent Oral Anticoagulant in Ischemic Stroke
Keimyung Author(s)(Kor)
박형종
Publisher
School of Medicine (의과대학)
Citation
Hyungjong Park and Joonsang Yoo. (2022). 허혈뇌졸중에서 비타민 K 비의존경구항응고제의 사용. 대한신경과학회지, 40(1), 1–14. doi: 10.17340/jkna.2022.1.1
Type
Article
ISSN
2288-985X
Source
https://www.jkna.org/journal/view.php?year=2022&vol=40&spage=1
DOI
10.17340/jkna.2022.1.1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44095
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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