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Clinical Implications of the Mitotic Index as a Predictive Factor for Malignant Transformation of Atypical Meningiomas

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Author(s)
Sae Min KwonJeong Hoon KimYoung-Hoon KimSeok Ho HongYoung Hyun ChoChang Jin KimSoo Jeong Nam
Keimyung Author(s)
Kwon, Sae Min
Department
Dept. of Neurosurgery (신경외과학)
Journal Title
J Korean Neurosurg Soc
Issued Date
2022
Volume
65
Issue
2
Keyword
Mitotic indexAtypical meningiomaMalignant transformation
Abstract
Objective:
Intracranial atypical meningiomas have a poor prognosis and high rates of recurrence. Moreover, up to one-third of the recurrences undergo high-grade transformation into malignant meningiomas. We aimed to investigate the clinical factors that can predict the propensity of malignant transformation from atypical to anaplastic meningiomas.

Methods:
Between 2001 and 2018, all patients with atypical meningioma, in whom the tumors had undergone malignant transformation to anaplastic meningioma, were included. The patients' medical records documenting the diagnosis of atypical meningioma prior to malignant transformation were reviewed to identify the predictors of transformation. The control group comprised 56 patients with atypical meningiomas who were first diagnosed between January 2017 and December 2018 and had no malignant transformation.

Results:
Nine patients in whom the atypical meningiomas underwent malignant transformation were included. The median time interval from diagnosis of atypical meningioma to malignant transformation was 19 months (range, 7-78). The study group showed a significant difference in heterogeneous enhancement (77.8% vs. 33.9%), bone invasion (55.6% vs. 12.5%), mitotic index (MI; 14.8±4.9 vs. 3.5±3.9), and Ki-67 index (20.7±13.9 vs. 9.5±7.1) compared with the control group. In multivariate analysis, increased MI (odds ratio, 1.436; 95% confidence interval, 1.127-1.900; p=0.004) was the only significant factor for predicting malignant transformation.

Conclusion:
An increased MI within atypical meningiomas might be used as a predictor of malignant transformation. Tumors at high risk for malignant transformation might require more attentive surveillance and management than other atypical meningiomas.
Keimyung Author(s)(Kor)
권세민
Publisher
School of Medicine (의과대학)
Citation
Sae Min Kwon et al. (2022). Clinical Implications of the Mitotic Index as a Predictive Factor for Malignant Transformation of Atypical Meningiomas. J Korean Neurosurg Soc, 65(2), 297–306. doi: 10.3340/jkns.2021.0114
Type
Article
ISSN
1598-7876
Source
https://www.jkns.or.kr/journal/view.php?number=7464
DOI
10.3340/jkns.2021.0114
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44097
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
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