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The Safety and Efficacy of Pregabalin Add-on Therapy in Restless Legs Syndrome Patients

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Author(s)
Hyoeun BaeYong Won ChoKeun Tae KimRichard P. AllenChristopher J. Earley
Keimyung Author(s)
Cho, Yong WonKim, Keun Tae
Department
Dept. of Neurology (신경과학)
Journal Title
Front Neurol
Issued Date
2021
Volume
12
Keyword
restless legs syndromepregabalindopamine agoniststreatmentadd-on
Abstract
Pregabalin is increasingly being used as a first-line treatment for symptomatic control of restless legs syndrome (RLS). This study aimed to evaluate the efficacy and safety of pregabalin as add-on therapy in RLS patients already taking dopamine agonists (DA) but still in need of further management. Patients with idiopathic RLS were enrolled, and all had already been prescribed DA for at least 3 months but still had either persistent symptoms, side effects, or comorbid insomnia. An initial dose of 75 mg pregabalin was begun, adjusted as needed, and maintained at a stable dose for 4 weeks, followed by observation for a total of 8 weeks. RLS symptoms and insomnia scores were evaluated before and after add-on pregabalin treatment. Patients were monitored for side effects that could be attributed to pregabalin. A total of 32 RLS patients were enrolled, and 20 subjects remained until the endpoint. After the pregabalin add-on, the mean IRLS score showed significant improvement compared to the baseline (p < 0.001). The insomnia severity index score also improved (p = 0.036), and no serious adverse effects were observed. Our preliminary data suggests the potential for pregabalin as an add-on therapy to DA with regards to both efficacy and safety in patients who have inadequate RLS improvement.
Keimyung Author(s)(Kor)
조용원
김근태
Publisher
School of Medicine (의과대학)
Citation
Hyoeun Bae et al. (2021). The Safety and Efficacy of Pregabalin Add-on Therapy in Restless Legs Syndrome Patients. Front Neurol, 12, 786408. doi: 10.3389/fneur.2021.786408
Type
Article
ISSN
1664-2295
Source
https://www.frontiersin.org/articles/10.3389/fneur.2021.786408/full
DOI
10.3389/fneur.2021.786408
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44121
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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