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Comparison between Cervical Ureaplasma spp. Colonization and the Intensity of Inflammatory Mediators in the Amniotic Fluid Retrieved during Cesarean Delivery in Preterm Birth

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Author(s)
Jingon BaeShin KimIlseon HwangJaehyun Park
Keimyung Author(s)
Bae, Jin GonKim, ShinHwang, Il SeonPark, Jae Hyun
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Immunology (면역학)
Dept. of Pathology (병리학)
Dept. of Pediatrics (소아청소년학)
Journal Title
Int J Environ Res Public Health
Issued Date
2022
Volume
19
Issue
1
Keyword
Ureaplasmachorioamnionitisamniotic fluidpreterm birth
Abstract
We investigated whether cervical Ureaplasma spp. colonization affects the intensity of inflammatory mediators in amniotic fluid retrieved during cesarean delivery in singleton preterm birth. One hundred fifty-three cases in singleton preterm birth with 24–34 weeks' gestation were enrolled. The intensities of seven inflammatory mediators (interleukin (IL)-1β, IL-6, IL-8, IL-10, tumor necrosis factor-α, and matrix metalloproteins (MMP)-8, MMP-9) of amniotic fluid were measured. We tested cervical swab specimens using real-time polymerase chain reaction assays to detect Ureaplasma spp. colonization. Histologic chorioamnionitis (HCA) was diagnosed when acute inflammation was observed in any of the placental tissues. Mean gestational age at delivery and birth weight were 30.9 ± 2.4 weeks and 1567 ± 524 g, respectively. Cervical Ureaplasma spp. colonization was detected 78 cases. The incidence of HCA was 32.3% (43/133). Although the intensities of all inflammatory mediators were significantly different according to presence or absence of HCA, there were no significant differences according to cervical Ureaplasma spp. colonization. In all 43 cases with HCA and 90 cases without HCA, there were no significant differences between cervical Ureaplasma spp. colonization and the intensity of inflammatory mediators. Cervical Ureaplasma spp. colonization did not affect the intensity of inflammatory mediators in the amniotic fluid retrieved during cesarean delivery.
Keimyung Author(s)(Kor)
배진곤
김신
황일선
박재현
Publisher
School of Medicine (의과대학)
Citation
Jingon Bae et al. (2022). Comparison between Cervical Ureaplasma spp. Colonization and the Intensity of Inflammatory Mediators in the Amniotic Fluid Retrieved during Cesarean Delivery in Preterm Birth. Int J Environ Res Public Health, 19(1), 107. doi: 10.3390/ijerph19010107
Type
Article
ISSN
1660-4601
Source
https://www.mdpi.com/1660-4601/19/1/107
DOI
10.3390/ijerph19010107
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44124
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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