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Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder

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Author(s)
Sooyeoun YouKyoung Sook WonKeun Tae KimHyang Woon LeeYong Won Cho
Keimyung Author(s)
You, Soo YeounWon, Kyoung SookKim, Keun TaeCho, Yong Won
Department
Dept. of Neurology (신경과학)
Dept. of Nuclear Medicine (핵의학)
Journal Title
J Clin Med
Issued Date
2021
Volume
10
Issue
22
Keyword
REM sleep behavior disorder (RBD)sleepautonomic dysfunction123I-metaiodobenzylguanidine (MIBG) scintigraphyREM sleep without atonia
Abstract
123I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was performed to assess cardiac autonomic dysfunction and demonstrate its correlation with clinical and polysomnographic characteristics in patients with isolated rapid eye movement (REM) sleep behavior disorder. All subjects including 39 patients with isolated REM sleep behavior disorder and 17 healthy controls underwent MIBG cardiac scintigraphy for cardiac autonomic dysfunction assessment. The isolated REM sleep behavior disorder was confirmed by in-lab overnight polysomnography. A receiver operating curve was constructed to determine the cut-off value of the early and delayed heart-to-mediastinum ratio in patients with isolated REM sleep behavior disorder. Based on each cut-off value, a comparison analysis of REM sleep without atonia was performed by dividing isolated REM sleep behavior disorder patients into two groups. MIBG uptake below the cut-off value was associated with higher REM sleep without atonia. The lower heart-to-mediastinum ratio had significantly higher REM sleep without atonia (%), both with cut-off values of early (11.0 ± 5.6 vs. 29.3 ± 23.2%, p = 0.018) and delayed heart-to-mediastinum ratio (9.1 ± 4.3 vs. 30.0 ± 22.9%, p = 0.011). These findings indicate that reduced MIBG uptake is associated with higher REM sleep without atonia in isolated REM sleep behavior disorder.
Keimyung Author(s)(Kor)
유수연
원경숙
김근태
조용원
Publisher
School of Medicine (의과대학)
Citation
Sooyeoun You et al. (2021). Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder. J Clin Med, 10(22), 5414. doi: 10.3390/jcm10225414
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/10/22/5414
DOI
10.3390/jcm10225414
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44126
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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