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Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer

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Author(s)
Hyeong Chan ShinIncheol SeoHasong JeongSang Jun ByunShin KimSung Uk BaeSun Young KwonHye Won Lee
Keimyung Author(s)
Shin, Hyeong Chan| Byun, Sang JunKim, ShinBae, Sung UkKwon, Sun YoungLee, Hye Won
Department
Dept. of Pathology (병리학)
Dept. of Radiation Oncology (방사선종양학)
Dept. of Immunology (면역학)
Dept. of Surgery (외과학)
Journal Title
Life (Basel)
Issued Date
2021
Volume
11
Issue
11
Keyword
tumor-associated macrophagescolorectal cancertumor microenvironmentprognosis
Abstract
This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.
Keimyung Author(s)(Kor)
신형찬
변상준
김신
배성욱
권선영
이혜원
Publisher
School of Medicine (의과대학)
Citation
Hyeong Chan Shin et al. (2021). Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer. Life (Basel), 11(11), 1240. doi: 10.3390/life11111240
Type
Article
ISSN
2075-1729
Source
https://www.mdpi.com/2075-1729/11/11/1240
DOI
10.3390/life11111240
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44140
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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