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Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia

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Author(s)
Jaekyoung LeeJin Gon BaeYu Cheol Kim
Keimyung Author(s)
Bae, Jin GonKim, Yu Cheol
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Ophthalmology (안과학)
Journal Title
PLoS One
Issued Date
2021
Volume
16
Issue
12
Abstract
This study aimed to evaluate the correlation between ophthalmologic factors and the serologic indicator soluble fms-like tyrosine kinase 1 (sFlt-1): placental growth factor (PlGF) ratio in patients with preeclampsia using optical coherence tomography (OCT) and OCT angiography (OCT-A). A total of 52 pregnant patients (104 eyes) diagnosed with preeclampsia were recruited during their hospital stay. The associations between the sFlt-1/PlGF ratio and chorioretinal measurements, including the choroidal thickness (CT), foveal avascular zone, vascular density, and ganglion cell layer+ were evaluated. Central and nasal subfield CT of the left eye (p = 0.039; p = 0.010) and nasal subfield CT of the right eye (p = 0.042) were lower in the high sFlt-1/PlGF ratio group (≥38). Pearson's correlation test showed a negative correlation between the sFlt-1/PlGF ratio and central subfield CT; however, this was not statistically significant (p = 0.648). Linear regression analysis revealed a significant association between the sFlt-1/PlGF ratio and central subfield CT (β coefficient, -6.66; p = 0.01) and between sFlt-1 and central subfield CT (β coefficient, -5.65; p = 0.00). Thus, an increase in the sFlt-1/PlGF ratio resulted in a decrease in central subfield CT.
Keimyung Author(s)(Kor)
배진곤
김유철
Publisher
School of Medicine (의과대학)
Citation
Jaekyoung Lee et al. (2021). Relationship between the sFlt-1/PlGF ratio and the optical coherence tomographic features of chorioretina in patients with preeclampsia. PLoS One, 16(12), e0261287. doi: 10.1371/journal.pone.0261287
Type
Article
ISSN
1932-6203
Source
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261287
DOI
10.1371/journal.pone.0261287
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44151
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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