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Second-generation non-hematopoietic erythropoietin-derived peptide for neuroprotection

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Author(s)
Bongki ChoSeung-Jun YooSo Yeon KimChang-Hun LeeYun-Il LeeSeong-Ryong LeeCheil Moon
Keimyung Author(s)
Lee, Seong Ryong
Department
Dept. of Pharmacology (약리학)
Journal Title
Redox Biol
Issued Date
2022
Volume
49
Keyword
ErythropoietinErythropoietin receptorPeptideNeuroprotectionHypoxiaIschemia
Abstract
Erythropoietin (EPO) is a well-known erythropoietic cytokine having a tissue-protective effect in various tissues against hypoxic stress, including the brain. Thus, its recombinants may function as neuroprotective compounds. However, despite considerable neuroprotective effects, the EPO-based therapeutic approach has side effects, including hyper-erythropoietic and tumorigenic effects. Therefore, some modified forms and derivatives of EPO have been proposed to minimize the side effects. In this study, we generated divergently modified new peptide analogs derived from helix C of EPO, with several amino acid replacements that interact with erythropoietin receptors (EPORs). This modification resulted in unique binding potency to EPOR. Unlike recombinant EPO, among the peptides, ML1-h3 exhibited a potent neuroprotective effect against oxidative stress without additional induction of cell-proliferation, owing to a differential activating mode of EPOR signaling. Furthermore, it inhibited neuronal death and brain injury under hypoxic stress in vitro and in an in vivo ischemic brain injury model. Therefore, the divergent modification of EPO-derivatives for affinity to EPOR could provide a basis for a more advanced and optimal neuroprotective strategy.
Keimyung Author(s)(Kor)
이성용
Publisher
School of Medicine (의과대학)
Citation
Bongki Cho et al. (2022). Second-generation non-hematopoietic erythropoietin-derived peptide for neuroprotection. Redox Biol, 49, 102223. doi: 10.1016/j.redox.2021.102223
Type
Article
ISSN
2213-2317
Source
https://www.sciencedirect.com/science/article/pii/S2213231721003839
DOI
10.1016/j.redox.2021.102223
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44152
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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