계명대학교 의학도서관 Repository

Robust response of pulmonary pleomorphic carcinoma to pembrolizumab and sequential radiotherapy: A case report

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Author(s)
Tae-Hun KimSun Hyo ParkIlseon HwangJin Hee LeeJin Hee KimHae Won KimHyun Jung Kim
Keimyung Author(s)
Park, Sun HyoHwang, Il SeonKim, Jin Hee
Department
Dept. of Pathology (병리학)
Dept. of Radiation Oncology (방사선종양학)
Dept. of Internal Medicine (내과학)
Journal Title
Respirol Case Rep
Issued Date
2021
Volume
9
Issue
12
Keyword
PD-L1pembrolizumabpulmonary pleomorphic carcinoma
Abstract
Pulmonary pleomorphic carcinoma (PPC) is a rare type of non-small cell lung cancer (NSCLC) with a more aggressive clinical course and a worse outcome than other types of NSCLC. Pembrolizumab, a monoclonal antibody targeting programmed cell death-1 (PD-1), has been approved as the first-line treatment for advanced NSCLC with robust PD-L1 expression in at least 50% of tumour cells, without epidermal growth factor receptor gene (EGFR) mutations or anaplastic lymphoma kinase gene (ALK) rearrangement. Here, we report the case of an 81-year-old man with multiple comorbidities who was diagnosed with PPC and showed a robust response to pembrolizumab followed by radiation therapy without adverse effects. In the absence of randomized clinical trials for PPCs, our case report demonstrates the potential application of pembrolizumab and radiation therapy for the treatment of PPCs.
Keimyung Author(s)(Kor)
박선효
황일선
김진희
Publisher
School of Medicine (의과대학)
Citation
Tae-Hun Kim et al. (2021). Robust response of pulmonary pleomorphic carcinoma to pembrolizumab and sequential radiotherapy: A case report. Respirol Case Rep, 9(12), e0875. doi: 10.1002/rcr2.875
Type
Article
ISSN
2051-3380
Source
https://onlinelibrary.wiley.com/doi/10.1002/rcr2.875
DOI
10.1002/rcr2.875
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44153
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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