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Clinical impact of left atrial enlargement in Korean patients with atrial fibrillation

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Author(s)
Min Soo ChoHyoung-Seob ParkMyung-Jin ChaSo-Ryoung LeeJin-Kyu ParkTae-Hoon KimJung Myung LeeJunbeom ParkHyung Wook ParkKi-Woon KangJaemin ShimJae-Sun UhmJin-Bae KimChangsoo KimYoung Soo LeeEue-Keun ChoiBoyoung JoungJun Kim
Keimyung Author(s)
Park, Hyoung Seob
Department
Dept. of Internal Medicine (내과학)
Journal Title
Sci Rep
Issued Date
2021
Volume
11
Issue
1
Abstract
We sought to evaluate the clinical implication of LAE based on left atrial anterior–posterior (LA AP) dimension or LA volume index (LAVI) in Korean patients with atrial fibrillation (AF). We enrolled 8159 AF patients from the CODE-AF registry. The primary outcome was rate of stroke or systemic embolism (SSE). The prevalence of mild, moderate, and severe LAE by LA AP dimension was 30.6%, 18.5%, and 21.4%, and by LAVI (available in 5808 patients) was 15.7%, 12.5% and 37.8%, respectively. Compared with no or mild LAE, patients with significant LAE (moderate to severe LAE, n = 3258, 39.9%) were associated with a higher rate of SSE (2.5% vs. 1.4%, P = 0.001). Multivariable analysis suggested presence of significant LAE by LA AP dimension was associated with a higher risk of SSE in the overall population (HR 1.57, 95% CI: 1.14–2.17, P = 0.005) and in patients using anticoagulants (n = 5836, HR 1.79, 95% CI: 1.23–2.63, P = 0.002). Patients with significant LAE by LAVI were also at higher risk of SSE (HR 1.58, 95% CI: 1.09–2.29, P = 0.017). In conclusion, significant LAE by LA dimension or LAVI was present in 39.9% and 50.2% of AF patients, respectively, and was associated with a higher rate of SSE.
Keimyung Author(s)(Kor)
박형섭
Publisher
School of Medicine (의과대학)
Citation
Min Soo Cho et al. (2021). Clinical impact of left atrial enlargement in Korean patients with atrial fibrillation. Sci Rep, 11(1), 23808. doi: 10.1038/s41598-021-03266-z
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-021-03266-z
DOI
10.1038/s41598-021-03266-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44155
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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