계명대학교 의학도서관 Repository

Impact of recipient and donor smoking in living-donor kidney transplantation: a prospective multicenter cohort study

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Author(s)
Hee-Yeon JungYena JeonKyu Ha HuhJae Berm ParkCheol Woong JungSik LeeSeungyeup HanHan RoJaeseok YangCurie AhnJang-Hee ChoSun-Hee ParkYong-Lim KimChan-Duck Kim
Keimyung Author(s)
Han, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Transpl Int
Issued Date
2021
Volume
34
Issue
12
Keyword
graft survivalkidney transplantationliving donorssmokingtransplant recipient
Abstract
The smoking status of kidney transplant recipients and living donors has not been explored concurrently in a prospective study, and the synergistic adverse impact on outcomes remains uncertain. The self-reported smoking status and frequency were obtained from recipients and donors at the time of kidney transplantation in a prospective multicenter longitudinal cohort study (NCT02042963). Smoking status was categorized as "ever smoker" (current and former smokers collectively) or "never smoker." Among 858 eligible kidney transplant recipients and the 858 living donors, 389 (45.3%) and 241 (28.1%) recipients were considered ever smokers at the time of transplant. During the median follow-up period of 6 years, the rate of death-censored graft failure was significantly higher in ever-smoker recipients than in never-smoker recipients (adjusted HR, 2.82; 95% CI 1.01–7.87; P = 0.048). A smoking history of >20 pack-years was associated with a significantly higher rate of death-censored graft failure than a history of ≤20 pack-years (adjusted HR, 2.83; 95% CI 1.19–6.78; P = 0.019). No donor smoking effect was found in terms of graft survival. The smoking status of the recipients and donors or both did not affect the rate of biopsy-proven acute rejection, major adverse cardiac events, all-cause mortality, or post-transplant diabetes mellitus. Taken together, the recipient's smoking status before kidney transplantation is dose-dependently associated with impaired survival.
Keimyung Author(s)(Kor)
한승엽
Publisher
School of Medicine (의과대학)
Citation
Hee-Yeon Jung et al. (2021). Impact of recipient and donor smoking in living-donor kidney transplantation: a prospective multicenter cohort study. Transpl Int, 34(12), 2794–2802. doi: 10.1111/tri.14137
Type
Article
ISSN
1432-2277
Source
https://onlinelibrary.wiley.com/doi/10.1111/tri.14137
DOI
10.1111/tri.14137
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44160
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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