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Postmastectomy Radiation Therapy for Node-Negative Breast Cancer of 5cm or Larger Tumors: A Multicenter Retrospective Analysis (KROG 20-03)

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Author(s)
Kyubo KimJinhong JungHaeyoung KimWonguen JungKyung Hwan ShinJi Hyun ChangSu Ssan KimWon ParkJee Suk ChangYong Bae KimSung Ja AhnIk Jae LeeJong Hoon LeeHae Jin ParkJihye ChaJuree Kima)Jin Hwa ChoiTaeryool KooJeanny KwonJin Hee KimMi Young KimShin-Hyung ParkYeon-Joo Kim
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Cancer Res Treat
Issued Date
2022
Volume
54
Issue
2
Keyword
Breast neoplasms≥5cmNode-negativeMastectomyRadiotherapy
Abstract
Purpose:
To evaluate the role of postmastectomy radiation therapy (PMRT) in patients with node-negative breast cancer of 5cm or larger tumors undergoing mastectomy

Materials and Methods:
Medical records of 274 patients from 18 institutions treated with mastectomy between Jan 2000 and Dec 2016 were retrospectively reviewed. Among these, 202 patients underwent PMRT, while 72 did not. Two hundred and forty-one patients (88.0%) received systemic chemotherapy, and 172 (62.8%) received hormonal therapy. Patients receiving PMRT were younger, more likely to have progesterone receptor-positive tumors, and received adjuvant chemotherapy more frequently compared with those without PMRT (p <0.001, 0.018, and <0.001, respectively). Other characteristics were not significantly different between the two groups.

Results:
With a median follow-up of 95 months (range, 1-249), there were 9 locoregional recurrences, and 20 distant metastases. The 8-year locoregional recurrence-free survival rates were 98.0% with PMRT and 91.3% without PMRT (p=0.133), and the 8-year disease-free survival (DFS) rates were 91.8% with PMRT and 73.9% without PMRT (p=0.008). On multivariate analysis incorporating age, histologic grade, lymphovascular invasion, hormonal therapy, chemotherapy, and PMRT, the absence of lymphovascular invasion and the receipt of PMRT were associated with improved DFS (p=0.025 and 0.009, respectively).

Conclusion:
Locoregional recurrence rate was very low in node-negative breast cancer of 5cm or larger tumors treated with mastectomy regardless of the receipt of PMRT. However, PMRT was significantly associated with improved DFS. Further investigation is needed to confirm these findings.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Kyubo Kim et al. (2022). Postmastectomy Radiation Therapy for Node-Negative Breast Cancer of 5cm or Larger Tumors: A Multicenter Retrospective Analysis (KROG 20-03). Cancer Res Treat, 54(2), 497–504. doi: 10.4143/crt.2021.933
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2021.933
DOI
10.4143/crt.2021.933
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44166
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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