계명대학교 의학도서관 Repository

Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries

Metadata Downloads
Author(s)
In Woong HanJangho ParkEun Young ParkSo Jeong YoonGang JinDae Wook HwangKuirong JiangWooil KwonXuefeng XuJin Seok HeoDe-Liang FuWoo Jung LeeXueli BaiYoo-Seok YoonYin-Mo YangKeun Soo AhnChunhui YuanHyeon Kook LeeBei SunEun Kyu ParkSeung Eun LeeSunghwa KangWenhui LouSang-Jae Park
Keimyung Author(s)
Ahn, Keun Soo
Department
Dept. of Surgery (외과학)
Journal Title
Cancers (Basel)
Issued Date
2022
Volume
14
Issue
4
Keyword
nonfunctioning neuroendocrine tumor of pancreasprognosisresectionrisk factors
Abstract
Several treatment guidelines for sporadic, nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) have recommended resection, however, tumors ≤ 2 cm do not necessarily need surgery. This study aims to establish a surgical treatment plan for NF-pNETs ≤ 2 cm. From 2000 to 2017, 483 patients who underwent resection for NF-pNETs ≤ 2 cm in 18 institutions from Korea and China were enrolled and their medical records were reviewed. The median age was 56 (range 16–80) years. The 10-year overall survival rate (10Y-OS) and recurrence-free survival rate (10Y-RFS) were 89.8 and 93.1%, respectively. In multivariable analysis, tumor size (>1.5 cm; HR 4.28, 95% CI 1.80–10.18, p = 0.001) and nodal metastasis (HR 3.32, 95% CI 1.29–8.50, p = 0.013) were independent adverse prognostic factors for OS. Perineural invasion (HR 4.36, 95% CI 1.48–12.87, p = 0.008) and high Ki-67 index (≥3%; HR 9.06, 95% CI 3.01–27.30, p < 0.001) were independent prognostic factors for poor RFS. NF-pNETs ≤ 2 cm showed unfavorable prognosis after resection when the tumor was larger than 1.5 cm, Ki-67 index ≥ 3%, or nodal metastasis was present. NF-pNET patients with tumors ≤ 1.5 cm can be observed if the preoperative Ki-67 index is under 3%, and if nodal metastasis is not suspected in preoperative radiologic studies. These findings support the clinical use to make decisions about small NF-pNETs.
Keimyung Author(s)(Kor)
안근수
Publisher
School of Medicine (의과대학)
Citation
In Woong Han et al. (2022). Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries. Cancers (Basel), 14(4), 1038. doi: 10.3390/cancers14041038
Type
Article
ISSN
2072-6694
Source
https://www.mdpi.com/2072-6694/14/4/1038
DOI
10.3390/cancers14041038
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44175
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.