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Gender Differences in All-Cause Mortality after Acute Myocardial Infarction: Evidence for a Gender-Age Interaction

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Author(s)
Pil Sang SongMi Joo KimSeok-Woo SeongSi Wan ChoiHyeon-Cheol GwonSeung-Ho HurSeung-Woon RhaChang-Hwan YoonMyung Ho JeongJin-Ok Jeong
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Clin Med
Issued Date
2022
Volume
11
Issue
3
Keyword
acute myocardial infarctiongender differencesinteraction term of gender with age
Abstract
Gender difference studies in mortality after acute myocardial infarction (AMI) have shown inconsistent results. A total of 13,104 patients from the KAMIR-NIH between November 2011 and December 2015 were classified into young (n = 3837 [29.3%]) and elderly (n = 9267 [70.7%]) patients. For the study, women <65 and men <55 years of age were considered “young”. In the adjusted model of the entire cohort, there was no significant difference in three-year all-cause mortality between women and men (17.8% vs. 10.3%; adjusted hazard ratio [HR], 0.953; 95% confidence interval [CI], 0.799–1.137). However, when the entire cohort was subdivided into two age groups, young women showed an 84.3% higher mortality rate than young men (adjusted HR, 1.843; 95% CI, 1.098–3.095). Contrariwise, elderly women patients had a 20.4% lower hazard of mortality compared with elderly men (adjusted HR, 0.796; 95% CI, 0.682–0.929). The interaction of gender with age was significant, even after multiple adjustments (adjusted p for interaction = 0.003). The purpose of this study was to assess whether gender differences depend on the patients’ age. Based on our analysis, higher mortality of young women remains even in the contemporary era of AMI. A better understanding of the mechanisms underlying these differences is warranted.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Pil Sang Song et al. (2022). Gender Differences in All-Cause Mortality after Acute Myocardial Infarction: Evidence for a Gender-Age Interaction. J Clin Med, 11(3), 541. doi: 10.3390/jcm11030541
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/11/3/541
DOI
10.3390/jcm11030541
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44193
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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