계명대학교 의학도서관 Repository

The association of genetic alterations with response rate in newly diagnosed chronic myeloid leukemia patients

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Author(s)
Hyunkyung ParkSungbong KangInho KimSangsoo KimHyeong-Joon KimDong-Yeop ShinDae-Young KimKyoo-Hyung LeeJae-Sook AhnSang-Kyun SohnJeong-Ok LeeJune-Won CheongKyoung Ha KimHoon-Gu KimHawk KimYoo Jin LeeSeung-Hyun NamYoung Rok DoSang-Gon ParkSeong Kyu ParkHun Ho SongChul Won JungSeonyang Park
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Leuk Res
Issued Date
2022
Volume
114
Keyword
Chronic myeloid leukemiaTyrosine kinaseGenetic analysisMolecular responseNatural killer cell
Abstract
Genetic differences may be associated with the response to tyrosine kinase inhibitor (TKI) in patients with chronic myeloid leukemia (CML). In this study, we identified genetic alterations between rapid and slow responders ( BCR/ABL1 International Scale at 6 months: ≤0.1 % vs. > 0.1 %) of TKI treatment in chronic phase CML patients. Our analyses involved single nucleotide polymorphism (SNP), a Genome Wide Association Study and a Network-wide Association Study (NetWAS). Seventy-two patients from 16 institutions were enrolled and treated with a TKI, nilotinib. Gene Set Analysis identified genetic alterations in pathways related to the differentiation, proliferation, and activity of various innate immune cells. The NetWAS analysis found that genes associated with natural killer (NK) cells ( PTPRCAP, BLNK, HCK, ARHGEF11, GPR183, TRPV2, SHKBP1, CD2 ) showed significant differences between rapid and slow responders of nilotinib. However, we found no significantly different genetic alterations according to the response in the SNP analysis. In conclusion, we found that rapidity of response to TKI was associated with pathway-associated genetic alterations in immune cells, particularly with respect to NK cell activity. These results suggested that the innate immune system at initial diagnosis had an important role in treatment response in patients with CML.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine (의과대학)
Citation
Hyunkyung Park et al. (2022). The association of genetic alterations with response rate in newly diagnosed chronic myeloid leukemia patients. Leuk Res, 114, 106791. doi: 10.1016/j.leukres.2022.106791
Type
Article
ISSN
0145-2126
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0145212622000170
DOI
10.1016/j.leukres.2022.106791
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44203
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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