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Antiviral Activities of High Energy E-Beam Induced Copper Nanoparticles against H1N1 Influenza Virus

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Author(s)
Taesung HaThi Tuyet Mai PhamMikyung KimYeon-Hee KimJi-Hyun ParkJi Hae SeoKyung-Min KimEunyoung Ha
Keimyung Author(s)
Seo, Ji HyeHa, Eun Young
Department
Dept. of Biochemistry (생화학)
Journal Title
Nanomaterials (Basel)
Issued Date
2022
Volume
12
Issue
2
Keyword
coppernanoparticleinfluenza virusantiviral activityelectron beam
Abstract
The pandemic outbreak of COVID-19 in the year of 2020 that drastically changed everyone’s life has raised the urgent and intense need for the development of more efficacious antiviral material. This study was designed to develop copper nanoparticles (Cu NPs) as an antiviral agent and to validate the antiviral activities of developed copper NP. The Cu NPs were synthesized using a high energy electron beam, and the characteristic morphologies and antiviral activities of Cu NPs were evaluated. We found that Cu NPs are of spherical shape and uniformly distributed, with a diameter of around 100 nm, as opposed to the irregular shape of commercially available copper microparticles (Cu MPs). An X-ray diffraction analysis showed the presence of Cu and no copper oxide II and I in the Cu NPs. A virus inactivation assay revealed no visible viral DNA after 10- and 30-min treatment of H1N1 virus with the Cu NPs. The infectivity of the Cu NPs-treated H1N1 virus significantly decreased compared with that of the Cu MPs-treated H1N1 virus. The viability of A549 bronchial and Madin-Darby Canine Kidney (MDCK) cells infected with Cu NPs-treated H1N1 was significantly higher than those infected with Cu MPs-treated H1N1 virus. We also found cells infected with Cu NPs-treated H1N1 virus exhibited a markedly decreased presence of virus nucleoprotein (NuP), an influenza virus-specific structural protein, compared with cells infected with Cu MPs-treated H1N1 virus. Taken together, our study shows that Cu NPs are a more effective and efficacious antiviral agent compared with Cu MPs and offer promising opportunities for the prevention of devastatingly infectious diseases.
Keimyung Author(s)(Kor)
서지혜
하은영
Publisher
School of Medicine (의과대학)
Citation
Taesung Ha et al. (2022). Antiviral Activities of High Energy E-Beam Induced Copper Nanoparticles against H1N1 Influenza Virus. Nanomaterials (Basel), 12(2), 268. doi: 10.3390/nano12020268
Type
Article
ISSN
2079-4991
Source
https://www.mdpi.com/2079-4991/12/2/268
DOI
10.3390/nano12020268
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44207
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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