계명대학교 의학도서관 Repository

Serological evaluation of patients with coronavirus disease-2019 in Daegu, South Korea

Metadata Downloads
Author(s)
Sunggyun ParkSoon Hee ChangJae Hee LeeJong Ho LeeJi Yeon HamYu Kyung KimSang-Gyung KimNam Hee Ryoo
Keimyung Author(s)
Park, Sung GyunRyoo, Nam Hee
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
PLoS One
Issued Date
2022
Volume
17
Issue
1
Abstract
Background:
Early and accurate detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to prevent spread of the infection. Understanding of the antibody response to SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19) is insufficient, particularly in relation to those whose responses persist for more than 1 month after the onset of symptoms. We conducted a SARS-CoV-2 antibody test to identify factors affecting the serological response and to evaluate its diagnostic utility in patients with COVID-19.

Methods and finding:
We collected 1,048 residual serum samples from 396 patients with COVID-19 confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. The samples had been used for routine admission tests in six healthcare institutions in Daegu. Antibody to SARS-CoV-2 was analyzed and the cutoff index (COI) was calculated for quantitative analysis. The patients’ information was reviewed to evaluate the relationship between antibody positivity and clinical characteristics. The anti-SARS-CoV-2 antibody positivity rate was 85% and the average COI was 24·3. The positivity rate and COI increased with time elapsed since symptom onset. Anti-SARS-CoV-2 antibody persisted for at least 13 weeks after symptom onset at a high COI. There was a significant difference in anti-SARS-CoV-2 antibody positivity rate between patients with and without symptoms, but not according to sex or disease course. The descending COI pattern at weeks 1 to 5 after symptom onset was significantly more frequent in patients who died than in those who recovered.

Conclusions:
Anti-SARS-CoV-2 antibody persisted for at least 13 weeks at a high COI in patients with COVID-19. A decreasing COI pattern up to fifth week may be associated with a poor prognosis of COVID-19. As new treatments and vaccines are introduced, it is important to monitor continuously the usefulness of anti-SARS-CoV-2 antibody assays.
Keimyung Author(s)(Kor)
박성균
류남희
Publisher
School of Medicine (의과대학)
Citation
Sunggyun Park et al. (2022). Serological evaluation of patients with coronavirus disease-2019 in Daegu, South Korea. PLoS One, 17(1), e0262820. doi: 10.1371/journal.pone.0262820
Type
Article
ISSN
1932-6203
Source
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262820
DOI
10.1371/journal.pone.0262820
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44213
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.