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The impact of cardiopulmonary exercise-derived scoring on prediction of cardio-cerebral outcome in hypertrophic cardiomyopathy

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Author(s)
Jae-Man LeeHyun-Bin ParkJin-Eun SongIn-Cheol KimJi-Hun SongHyungseop KimJaewon OhJong-Chan YounGeu-Ru HongSeok-Min Kang
Keimyung Author(s)
Kim, In CheolKim, Hyung Seop
Department
Dept. of Internal Medicine (내과학)
Journal Title
PLoS One
Issued Date
2022
Volume
17
Issue
1
Abstract
Background:
Sudden cardiac death (SCD) and stroke-related events accompanied by atrial fibrillation (AF) can affect morbidity and mortality in hypertrophic cardiomyopathy (HCM). This study sought to evaluate a scoring system predicting cardio-cerebral events in HCM patients using cardiopulmonary exercise testing (CPET).

Methods:
We investigated the role of a previous prediction model based on CPET, the HYPertrophic Exercise-derived Risk score for Heart Failure-related events (HyperHF), which is derived from peak circulatory power ventilatory efficiency and left atrial diameter (LAD), for predicting a composite of SCD-related (SCD, serious ventricular arrhythmia, death from cardiac cause, heart failure admission) and stroke-related (new-onset AF, acute stroke) events. The Novel HyperHF risk model using left atrial volume index (LAVI) instead of LAD was proposed and compared with the previous HCM Risk-SCD model.

Results:
A total of 295 consecutive HCM patients (age 59.9±13.2, 71.2% male) who underwent CPET was included in the present study. During a median follow-up of 742 days (interquartile range 384–1047 days), 29 patients (9.8%) experienced an event (SCD-related event: 14 patients (4.7%); stroke-related event: 17 patients (5.8%)). The previous model for SCD risk score showed fair prediction ability (AUC of HCM Risk-SCD 0.670, p = 0.002; AUC of HyperHF 0.691, p = 0.001). However, the prediction power of Novel HyperHF showed the highest value among the models (AUC of Novel HyperHF 0.717, p<0.001).

Conclusions:
Both conventional HCM Risk-SCD score and CPET-derived HyperHF score were useful for prediction of overall risk of SCD-related and stroke-related events in HCM. Novel HyperHF score using LAVI could be utilized for a better prediction power.
Keimyung Author(s)(Kor)
김인철
김형섭
Publisher
School of Medicine (의과대학)
Citation
Jae-Man Lee et al. (2022). The impact of cardiopulmonary exercise-derived scoring on prediction of cardio-cerebral outcome in hypertrophic cardiomyopathy. PLoS One, 17(1), e0259638. doi: 10.1371/journal.pone.0259638
Type
Article
ISSN
1932-6203
Source
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0259638
DOI
10.1371/journal.pone.0259638
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44215
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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