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Adverse Events Associated With Peroral Endoscopic Myotomy Affecting Extended Hospital Stay: A Multi-center Retrospective Study in South Korea

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Author(s)
Ju Yup LeeChul-Hyun LimDo Hoon KimHwoon-Yong JungYoung Hoon YounDa Hyun JungJun Chul ParkHee Seok MoonSu Jin Hong
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Neurogastroenterol Motil
Issued Date
2022
Volume
28
Issue
2
Keyword
AchalasiaAdverse eventsEndoscopic myotomyEsophageal motility disorderHospital stay
Abstract
Background/Aims:
To analyze various adverse events (AEs) related to the peroral endoscopic myotomy (POEM) procedure and to analyze whether these AEs are related to an extended hospital stay.

Methods:
Patients admitted for POEM for esophageal motility disorders from August 2012 to February 2020 at 5 centers were retrospectively collected. Length of hospital stay, AEs during or after the POEM procedure were analyzed.

Results:
Of the 328 patients, 63.1% did not have any AEs, but 2.4% had major AEs, and 33.4% had minor AEs. Major AEs included mucosal injury, bleeding, and hemothorax, accounting for 1.5%, 0.6%, and 0.3%, respectively. Among the minor AEs, pneumoperitoneum was the most common gas-related AEs. Among non-gas-related minor AEs, pneumonia was the most common at 4.6%, followed by pain, fever, and pleural effusion. All major AEs had meaningful delayed discharge and significantly extended hospital stay compared to the no AEs group (median differences range 4.5-9.0 days). Among gas-related minor AEs, except for 4 cases of emphysema, the extended hospital stay was meaningless. All non-gas-related minor AEs was associated with a significant prolongation of hospital stay compared to that in the no AEs group (median differences range 2.0-4.0 days).

Conclusions:
In conclusion, most gas-related minor AEs do not significantly affect the patient’s clinical course. However, subcutaneous emphysema and minor non-gas related AEs such as pneumonia, pain, fever, and pleural effusion can prolong the hospital stay, therefore careful observation is required. Efforts will be made to reduce major AEs that significantly prolong hospitalization.
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine (의과대학)
Citation
Ju Yup Lee et al. (2022). Adverse Events Associated With Peroral Endoscopic Myotomy Affecting Extended Hospital Stay: A Multi-center Retrospective Study in South Korea. J Neurogastroenterol Motil, 28(2), 247–254. doi: 10.5056/jnm21081
Type
Article
ISSN
2093-0887
Source
https://www.jnmjournal.org/journal/view.html?uid=1756&vmd=Full&
DOI
10.5056/jnm21081
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44229
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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