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Clinical and Prognostic Values of DNMT3B Expression in Hepatocellular Carcinoma

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Author(s)
김종완박재희이재호
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Keimyung Med J
Issued Date
2022
Volume
41
Issue
1
Keyword
CarcinomahepatocellularDNMT3BMethylationThe Cancer Genome Atlas
Abstract
DNA methyltransferase 3B (DNMT3B), one of DNA methyltransferases has many roles in DNA methylation and cancer pathogenesis. However, its clinical and prognostic value was not studied in hepatocellular carcinoma (HCC). In this study, we analyzed DNMT3B expression in HCC by public big data, The Cancer Genome Atlas. Primary data about total 360 HCC were downloaded and its clinicopathological implication was analyzed. M stage (p = 0.07) and pathologic stage (p = 0.04) were associated with DNMT3B expression, though M stage did not get a statistical significance. And alpha fetoprotein level was positively correlated with DNMT3B expression (p < 0.001). Higher DNMT3B expression predicted shorter overall survival in HCC patients (p < 0.05). Disease-free survival was shorter in HCC with lower DNMT3B expression, within borderline statistical significance (p = 0.081). It suggested that DNMT3B expression may have an important role in HCC prognosis and its detail mechanism should be confirmed further.
Keimyung Author(s)(Kor)
이재호
Type
Journal
Source
https://www.e-kmj.org/journal/view.php?number=2252
DOI
10.46308/kmj.2022.00045
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44240
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2022
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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