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Current Prevalence of the crpP Gene in Carbapenemase-Producing Pseudomonas aeruginosa Blood Isolates in Korea

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Author(s)
Jinho HeoYu Jeong ChoiYoung Ah KimSeok Hoon JeongJong Hee ShinKyeong Seob ShinJeong Hwan ShinYoung Ree KimHyun Soo KimYoung UhNam Hee Ryoo
Keimyung Author(s)
Ryoo, Nam Hee
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Ann Clin Microbiol
Issued Date
2022
Volume
25
Issue
2
Keyword
FluoroquinoloneResistancecrpP genePseudomonas aeruginosa
Abstract
Background:
Recently, crpP enzymes have been described as a novel cause of ciprofloxacin resistance. The crpP gene encodes a novel protein that specifically confers resistance to ciprofloxacin through an adenosine triphosphate-dependent mechanism that phosphorylates the antimicrobial. In this study, the current prevalence of the crpP gene in carbapenemase-producing Pseudomonas aeruginosa blood isolates was evaluated.

Methods:
During the study of the Antimicrobial Resistance Surveillance System in Korea, 22 blood isolates of carbapenemase-producing P. aeruginosa were collected from nine general hospitals and two nursing homes in the year 2020. Resistance genes and phylogenic trees were analyzed with the whole genome sequencing data.

Results:
A total of 11 P. aeruginosa blood isolates coharbored the crpP and carbapenemase genes (nine IMP-6 producers and two GES-5-producers). Nine NDM-1-producers coharbored aac(6')-Ib-cr and qnrVC1. One GES-9-producer also carried aac(6')-Ib-cr, and one NDM-1-producer also carried qnrVC1. The phylogenic tree showed no epidemiologic link among the 22 carbapenemase-producing P. aeruginosa isolates.

Conclusion:
This is the first report on the current prevalence of the crpP gene in carbapenemase-producing P. aeruginosa blood isolates in Korea.
Alternative Title
국내 혈액분리 카바페넴 분해효소 생성 녹농균에서의 crpP 유전자 확산 현황
Keimyung Author(s)(Kor)
류남희
Publisher
School of Medicine (의과대학)
Citation
Jinho Heo et al. (2022). Current Prevalence of the crpP Gene in Carbapenemase-Producing Pseudomonas aeruginosa Blood Isolates in Korea. Ann Clin Microbiol, 25(2), 59–65. doi: 10.5145/ACM.2022.25.2.4
Type
Article
ISSN
2288-6850
Source
https://www.acm.or.kr/article_aws/?num=ACM_22-008
DOI
10.5145/ACM.2022.25.2.4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44247
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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