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Local complications are related to poor long-term outcome in patients undergoing curative gastrectomy for advanced gastric cancer

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Author(s)
Tae Sun HaGyu Seok ChoEung Jin ShinSeung Wan RyuKeun Won RyuMin Chan KimWoo Jin HyungChan Young KimHyuk-Joon LeeDong Woo ShinJun Ho Lee
Keimyung Author(s)
Ryu, Seung Wan
Department
Dept. of Surgery (외과학)
Journal Title
Korean J Clin Oncol
Issued Date
2022
Volume
18
Issue
1
Keyword
Stomach neoplasmsPostoperative complicationTumor recurrence
Abstract
Purpose:
The present study was performed to investigate the effects of local complications (LC) on long-term survival and cancer recurrence in patients undergoing curative gastrectomy for gastric cancer.

Methods:
We analyzed 2,627 patients after curative gastrectomy for gastric cancer between January 2001 and December 2006. Patients were classified into groups no complications (NC), LC, or systemic complications (SC).

Results:
Among the 2,627 patients, 475 patients developed complications (LC group [n=374, 14.2%] and SC group [n=101, 3.9%]). The 5-year cancer-specific survival rate was significantly poorer in the LC group compared to the NC and SC groups (LC, 78.0%; NC, 85.4%; SC, 80.2%; P=0.007). The occurrence of LC was identified as a significant independent prognostic factor for overall and cancer-specific survival (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.46–2.97; P=0.001 and HR, 1.77; 95% CI, 1.12–2.81; P=0.015). The tumor recurrence rates were higher in the LC group than the in other two groups (LC, 23.5%; NC, 15.4%; SC, 15.8%; P<0.001). The occurrence of LC was an independent predictor of tumor recurrence in patients undergoing curative gastrectomy for gastric cancer (HR, 1.55; 95% CI, 1.11–2.17; P=0.011).

Conclusion:
LC are associated with adverse long-term outcomes in patients after curative gastrectomy for advanced gastric cancer.
Keimyung Author(s)(Kor)
류승완
Publisher
School of Medicine (의과대학)
Citation
Tae Sun Ha et al. (2022). Local complications are related to poor long-term outcome in patients undergoing curative gastrectomy for advanced gastric cancer. Korean J Clin Oncol, 18(1), 36–46. doi: 10.14216/kjco.22005
Type
Article
ISSN
2288-4084
Source
http://www.kjco.org/journal/view.php?number=391
DOI
10.14216/kjco.22005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44260
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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