Low-dose clozapine monotherapy for recurrent non-suicidal self-injury: A case report
- Author(s)
- Jae-Won Yang; Sung-Won Jung; Hojun Lee
- Keimyung Author(s)
- Jung, Sung Won; Lee, Ho Jun
- Department
- Dept. of Psychiatry (정신건강의학)
- Journal Title
- Asian J Psychiatr
- Issued Date
- 2022
- Volume
- 73
- Keyword
- Clozapine; Non-suicidal self-injury; Adolescents; Depression; Suicidal ideation
- Abstract
- Non-suicidal self-injury (NSSI) is a challenging issue in clinical settings. In the present case series, we report two female adolescents with recurrent depression and NSSI. Numerous approaches, such as anti-depressants, anti-psychotics, and even electroconvulsive therapy, were not effective. Clozapine has been implemented in a broad spectrum of psychiatric disorders, particularly refractory depression, impulse control problems, suicidal ideation, and NSSI. With a low dose (12.5–25 mg) of clozapine, the depressive symptoms and NSSI remarkably improved, and the improvement was sustained over four months after discharge. Low-dose clozapine monotherapy may be a treatment option with refractory depression and NSSI.
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