계명대학교 의학도서관 Repository

Age-related difference in the impact of diabetes mellitus on all-cause mortality after acute myocardial infarction

Metadata Downloads
Author(s)
Pil Sang SongKye Taek AhnMi Joo KimSeok-Woo SeongSi Wan ChoiHyeon-Cheol GwonSeung-Ho HurSeung-Woon RhaChang-Hwan YoonMyung Ho JeongJin-Ok Jeong
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Metab
Issued Date
2022
Volume
48
Issue
4
Keyword
Acute myocardial infarctionDiabetes mellitusAgePrognosis
Abstract
Aim:
To test the hypothesis that the impact of diabetes mellitus on clinical outcomes after acute myocardial infarction (AMI) can vary by age.

Methods:
A total of 12,600 AMI patients from the Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015 was classified into young ( n = 3,590 [ 29% ]) and old ( n = 9,010 [ 72% ]). Those less than 55 years of age were considered young. We performed comparisons of baseline characteristics, in-hospital treatments, and 3-year clinical outcomes between patients with and without diabetes after stratification according to age group.

Results:
The prevalence of diabetes mellitus was 27 % in the young AMI group. In the multivariable adjusted model of the entire cohort, diabetes mellitus was associated strongly with 3-year all-cause mortality ( 13 % vs. 6.8%; adjusted hazard ratio [HR], 1.318; 95% confidence interval [CI], 1.138–1.526; P <0.001). When the entire cohort was subdivided into two age groups, young diabetic patients showed a 107% higher mortality rate than those without diabetes ( adjusted HR, 2.07 [1.15 – 3.72]; P = 0.015 ). Meanwhile, old diabetic patients had a 25% higher risk of mortality than non-diabetic patients ( adjusted HR, 1.25 [1.08 – 1.46]; P = 0.004 ). The interaction of diabetes with age was significant (adjusted P for interaction = 0.008).

Conclusions:
Diabetes mellitus is not uncommon in younger AMI patients, and the relative risk of 3-year mortality is significantly higher in young patients than in older counterparts. More aggressive treatments are needed to prevent future cardiovascular events in younger patients after AMI.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Pil Sang Song et al. (2022). Age-related difference in the impact of diabetes mellitus on all-cause mortality after acute myocardial infarction. Diabetes Metab, 48(4), 101349. doi: 10.1016/j.diabet.2022.101349
Type
Article
ISSN
1262-3636
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1262363622000325
DOI
10.1016/j.diabet.2022.101349
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44304
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.