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Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea

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Author(s)
Kim HSYu JM, Jang HC, Choi EK, Park JH, Shon HS, Chung CHPark KG, Cho JH, Kim WLee KH, Lee JH, Yoo SJ
Keimyung Author(s)
Kim, Hye Soon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Metab Syndr Obes
Issued Date
2022
Volume
15
Keyword
glycated hemoglobininsulin glulisineintensificationRAI analogs
Abstract
Purpose:
Although rapid-acting insulins (RAIs) are used frequently in Korean clinical settings, evidence on their use is limited. This study explores the pattern and clinical effectiveness of the use of RAIs in Korean patients with type 2 diabetes mellitus (T2DM).

Patients and Methods:
This non-interventional, observational study enrolled patients (aged > 18 years) with T2DM who were prescribed RAIs. The pattern of use and effectiveness of RAI analogs were evaluated over 6 months.

Results:
A total of 299/451 patients were analyzed. Approximately 90% (n/N=270/299) of the patients received insulin glulisine, which significantly reduced their levels of glycated hemoglobin (HbA1c: n=270, mean± standard deviation [SD]; − 1.16± 6.02%, p=0.0017), fasting plasma glucose (n=40; mean±SD: − 54.9± 90.89 mg/dl, p=0.0005), and post prandial blood glucose (n=35, mean±SD: − 89.46± 105.68 mg/dl, p< 0.0001) at 6 months, with a corresponding increase in body weight (BW) (n=197, mean±SD:1.45± 3.64 kg, p< 0.0001). At 6 months, more patients receiving an intensive regimen (basal insulin+≥ 2 RAI injections/day) had HbA1c < 7% than those receiving a non-intensive regimen (basal insulin+1 RAI injection/day) (20.69% vs 7.46%; p=0.0333); the corresponding reduction in HbA1c was also higher in patients receiving the intensive regimen (p< 0.0001). About one-fourth patients (n/N=22/95) were switched to the intensive regimen (from 1 to ≥ 2 RAI injections/day), and only 4.41% (n/N=9/204) of the patients were switched to 1 RAI injection/day. The patients receiving the intensive regimen showed higher levels of HbA1c reductions (mean±SD: − 1.27± 1.96%) compared with the maintenance group-1 RAI injection/day (mean±SD: − 0.72± 1.66%) (p=0.0459), without a significant increase in BW and body mass index.

Conclusion:
The insulin glulisine intensification regimen showed glycemic target achievement and can be considered a therapeutic tool in the management of T2DM patients.
Keimyung Author(s)(Kor)
김혜순
Publisher
School of Medicine (의과대학)
Citation
Kim HS et al. (2022). Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea. Diabetes Metab Syndr Obes, 15, 1495–1503. doi: 10.2147/DMSO.S334944
Type
Article
ISSN
1178-7007
Source
https://www.dovepress.com/real-world-analysis-of-rapid-acting-insulin-analog-use-and-its-blood-g-peer-reviewed-fulltext-article-DMSO
DOI
10.2147/DMSO.S334944
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44305
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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