계명대학교 의학도서관 Repository

Renal safety of tenofovir disoproxil fumarate and entecavir in liver transplant patients: a nationwide Korean registry study

Metadata Downloads
Author(s)
Juhan LeeJae Geun LeeShin HwangKwang-Woong LeeJong Man KimJe Ho RyuBong-Wan KimDong Lak ChoiYoung Kyoung YouDong-Sik KimYang Won NahKoo Jeong KangJai Young ChoHee Chul YuGeun HongDongho ChoiJu Ik MoonMyoung Soo Kim
Keimyung Author(s)
Kang, Koo Jeong
Department
Dept. of Surgery (외과학)
Journal Title
Hepatol Int
Issued Date
2022
Volume
16
Keyword
Liver transplantationHepatitis B virusEntecavirTenofovirRenal dysfunction
Abstract
Background and aims:
Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) have been recommended after liver transplantation to prevent recurrence of hepatitis B virus infection. Despite its proven efficacy, the renal safety of TDF has not been established in liver transplant recipients. We aimed to compare the effects of TDF and ETV on renal function in liver transplant recipients and to evaluate risk factors for renal dysfunction after liver transplantation.

Methods:
This is a retrospective, observational multicenter study of data from the Korean Organ Transplantation Registry. We included adults who underwent liver transplantation for hepatitis B virus-related complications from April 2014 to December 2017 and received TDF or ETV post-transplantation. Renal dysfunction was defined as an estimated glomerular filtration rate decline by at least 20% from baseline (1 month post-transplantation). Median duration of follow-up was 29 months (interquartile range 19–42).

Results:
A total of 804 liver transplant patients were included. The cumulative probability of renal dysfunction was significantly higher in the TDF group than in the ETV group. Multivariable analysis confirmed that TDF was independently associated with an increased risk of renal dysfunction (hazard ratio = 1.47, 95% confidence interval 1.12–1.92; p = 0.005). Independent risk factors for renal dysfunction included older age, worse baseline renal function, and low body mass index. Overall survival rate was significantly lower in patients with renal dysfunction than in those without.

Conclusions:
In this nationwide study, the use of TDF was associated with an increased risk of renal dysfunction, when compared with ETV.
Keimyung Author(s)(Kor)
강구정
Publisher
School of Medicine (의과대학)
Citation
Juhan Lee et al. (2022). Renal safety of tenofovir disoproxil fumarate and entecavir in liver transplant patients: a nationwide Korean registry study. Hepatol Int, 16, 537–544. doi: 10.1007/s12072-022-10320-z
Type
Article
ISSN
1936-0541
Source
https://link.springer.com/article/10.1007/s12072-022-10320-z
DOI
10.1007/s12072-022-10320-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44312
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.