계명대학교 의학도서관 Repository

Korean Adolescent Patient with Manifestations of Lymphocyte Variant Hypereosinophilic Syndrome and Episodic Angioedema with Eosinophilia, Treated with Reslizumab

Metadata Downloads
Author(s)
Jie Hee JueYe Jee ShimSunggyun ParkDo-Hoon KimHye Ra Jung
Keimyung Author(s)
Shim, Ye JeePark, Sung GyunKim, Do HoonJung, Hye Ra
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Pathology (병리학)
Journal Title
Iran J Allergy Asthma Immunol
Issued Date
2022
Volume
21
Issue
2
Keyword
AngioedemaEosinophiliaHypereosinophilic syndromeInterleukin-5Monoclonal antibodiesyReslizumab
Abstract
A four-year-old female patient visited the pediatric hematologic clinic due to periodic generalized edema and eosinophilia. Laboratory assessment showed an eosinophil count of 40.02×109/L (73.6% of white blood cells). A bone marrow aspirate smear film showed no signs of malignant cells but had hypercellular marrow particles with eosinophilia (45% of all nucleated cells) and 52% of eosinophils were immature. Other laboratory tests showed an increased IgM level of 827 mg/dL, and lymphocyte phenotyping by flow cytometry revealed an aberrant CD3−CD4+ T-cell population of 27–53×109/L (1.9–3.6% of lymphocytes). Polymerase chain reaction analysis for the T-cell receptor gamma gene rearrangement showed a T-cell clonality peak. At the age of 13, allogeneic stem cell transplantation was performed, but with primary rejection. From the age of 17, she has continued receiving 3 mg/kg of reslizumab intravenously every 4 weeks for 21 months. Since reslizumab treatment was initiated, her eosinophil count remained consistently within the normal range. This is the first report describing the effective use of reslizumab in a Korean adolescent patient for the management of lymphocytic-variant hypereosinophilic syndrome (L-HES). Since the patient showed clinical manifestations of L-HES as well as episodic angioedema with eosinophilia (EAE), a continuous periodic examination is required given the higher risk of developing lymphoma or leukemia.
Keimyung Author(s)(Kor)
심예지
박성균
김도훈
정혜라
Publisher
School of Medicine (의과대학)
Citation
Jie Hee Jue et al. (2022). Korean Adolescent Patient with Manifestations of Lymphocyte Variant Hypereosinophilic Syndrome and Episodic Angioedema with Eosinophilia, Treated with Reslizumab. Iran J Allergy Asthma Immunol, 21(2), 215–218. doi: 10.18502/ijaai.v21i2.9229
Type
Article
ISSN
1735-5249
Source
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3216
DOI
10.18502/ijaai.v21i2.9229
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44314
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.