계명대학교 의학도서관 Repository

Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool

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Author(s)
Ji-Won KimSunghoon ParkJu-Yang JungHyoun-Ah KimSeong-Ryul KwonSang Tae ChoiSung-Soo KimSang-Hyeon KimChang-Hee Suh
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Clin Med
Issued Date
2022
Volume
11
Issue
10
Keyword
ankylosing spondylitisosteoporosisosteoporotic fracturebone mineral densityfracture risk assessment tool
Abstract
Background:
We investigated the prevalence of and the factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS).

Methods:
This was a multicenter, retrospective study including 219 AS patients from five university hospitals; the control group was selected by matching age and sex with those of the AS patients. The fracture risk was evaluated based on bone mineral density (BMD) measured by dual-energy X-ray absorptiometry and the fracture risk assessment tool (FRAX) with/without BMD.

Results:
The mean age of the patients was 47.6 years, and 144 (65.8%) patients were men. According to the WHO criteria and FRAX with/without BMD, the candidates for pharmacological treatment were 44 (20.1%), 20 (13.2%), and 23 (15.1%) patients, respectively, significantly more than those in the healthy control group. Among them, the proportion of patients receiving osteoporosis treatment was 39.1–75%. In logistic regression analysis, menopause was an independent factor for the high risk of fracture according to the WHO criteria and FRAX with/without BMD. C-reactive protein level (odds ratio (OR) 3.8 and OR 6) and glucocorticoid use (OR 1.5 and OR 1.7) were associated with a high risk of osteoporotic fracture based on FRAX without BMD and osteoporosis diagnosed according to the WHO criteria.

Conclusions:
Our study suggests that both FRAX and WHO criteria may be complementary for treatment decisions to reduce osteoporotic fractures in patients with AS.
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine (의과대학)
Citation
Ji-Won Kim et al. (2022). Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool. J Clin Med, 11(10), 2830. doi: 10.3390/jcm11102830
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/11/10/2830
DOI
10.3390/jcm11102830
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44320
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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