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Association between Three Waist Circumference-Related Obesity Metrics and Estimated Glomerular Filtration Rates

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Author(s)
Dong Yoon LeeGyeong Im YuYu-Mi KimMi Kyung KimMin-Ho ShinMi-Young Lee
Keimyung Author(s)
Lee, Mi Young
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
J Clin Med
Issued Date
2022
Volume
11
Issue
10
Keyword
body mass indexthe residual methodchronic kidney diseaseestimated glomerular filtration rateobesitywaist circumferencewaist-to-hip ratiowaist-to-height ratiowaist-to-height0.5 ratio
Abstract
Studies that have assessed the associations between obesity and the estimated glomerular filtration rate (eGFR) have reported inconsistent results. This cross-sectional study was performed to investigate the associations between three waist circumference (WC)-related obesity metrics (waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and waist-to-height0.5 ratio (WHt.5R)) and eGFRs. This study included 2133 men and 3443 women who were older than 40 years with eGFRs ≥ 60 mL/min/1.73 m² from the Korean Multi-Rural Communities Cohort. We calculated the residual body mass index (BMI) to reduce multicollinearity among the obesity metrics and performed multiple linear regression. For both sexes, among the adjusted models, most of the general obesity metrics were significantly associated with eGFRs. Particularly for women, the WC-related and general obesity metrics had a stronger effect on eGFRs in the quartile models that included the BMI and the residual BMI, respectively. When WC-related obesity metrics had a stronger effect than the general obesity metric, for both sexes, WHtR showed a significant impact than WHt.5R and WHR on eGFRs. Reducing multicollinearity had an important role in assessing the obesity metrics’ association with eGFRs. Overall, applying the residual method in further studies might help with evaluating the obesity paradox on renal function.
Keimyung Author(s)(Kor)
이미영
Publisher
School of Medicine (의과대학)
Citation
Dong Yoon Lee et al. (2022). Association between Three Waist Circumference-Related Obesity Metrics and Estimated Glomerular Filtration Rates. J Clin Med, 11(10), 2876. doi: 10.3390/jcm11102876
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/11/10/2876
DOI
10.3390/jcm11102876
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44321
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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