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Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio Combined With Anemia in Patients With ST-Segment Elevation Myocardial Infarction: A Nationwide Prospective Cohort Study

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Author(s)
Kyung Hoon ChoMin-Ho ShinMin Chul KimDoo Sun SimYoung Joon HongJu Han KimYoungkeun AhnShung Chull ChaeIn Whan SeongJong-Seon ParkChang-Hwan YoonSeung Ho HurSang Rok LeeMyung Ho Jeong
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Lipid Atheroscler
Issued Date
2022
Volume
11
Issue
2
Keyword
AnemiaLymphocytesNeutrophilsST elevation myocardial infarction
Abstract
Objective:
Data pertaining to the prognostic value of the combination of high neutrophil-to-lymphocyte ratio (NLR) and anemia on admission in patients with ST-segment elevation myocardial infarction (STEMI) are limited. The objective of this study was to investigate the clinical value of baseline NLR in combination with anemia in predicting clinical outcomes after STEMI.

Methods:
A total of 5,194 consecutive patients with STEMI within 12 hours of symptom onset from the Korea Acute Myocardial Infarction Registry-National Institute of Health database between 2011 and 2015 were categorized into 4 groups according to their NLR and hemoglobin levels: low NLR (<4) without anemia (n=2,722; reference group); high NLR (≥4) without anemia (n=1,527); low NLR with anemia (n=508); and high NLR with anemia (n=437). The co-primary outcomes were 180-day and 3-year all-cause mortality.

Results:
Mortality rates significantly increased at the 3-year follow-up across the groups (3.3% vs. 5.4% vs. 16.5% vs. 21.7% for 180-day mortality and 5.3% vs. 9.0% vs. 23.8% vs. 33.4% for 3-year mortality; all p-trends <0.001). After adjusting for baseline covariates, the combination of high NLR and anemia was a significant predictor of 180-day mortality after STEMI with low NLR and no anemia as the reference (adjusted hazard ratio, 2.16; 95% confidence interval, 1.58–2.95; p<0.001). Similar findings were observed for the 3-year mortality.

Conclusions:
This nationwide prospective cohort study showed that the combination of high NLR (≥4) and anemia is a strong predictor of all-cause mortality after STEMI.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Kyung Hoon Cho et al. (2022). Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio Combined With Anemia in Patients With ST-Segment Elevation Myocardial Infarction: A Nationwide Prospective Cohort Study. J Lipid Atheroscler, 11(2), 147–160. doi: 10.12997/jla.2022.11.2.147
Type
Article
ISSN
2288-2561
Source
https://e-jla.org/DOIx.php?id=10.12997/jla.2022.11.2.147
DOI
10.12997/jla.2022.11.2.147
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44330
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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