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Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY)

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Author(s)
Jong Cheol JeongTai Yeon KooHan RoDong Ryeol LeeDong Won LeeJieun OhJayoun KimDong-Wan ChaeYoung Hoon KimKyu Ha HuhJae Berm ParkYeong Hoon KimSeungyeup HanSoo Jin Na ChoiSik LeeSang-Il MinJongwon HaMyoung Soo KimCurie AhnJaeseok Yang
Keimyung Author(s)
Han, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Sci Rep
Issued Date
2022
Volume
12
Abstract
Data for Asian kidney transplants are very limited. We investigated the relative importance of prognostic markers in Asian kidney transplants by using Korean Organ Transplantation Registry (KOTRY) cohort. Prediction models were developed by data-driven variable selection approach. The relative importance of the selected predictors was measured by dominance analysis. A total of 4854 kidney transplant donor-recipient pairs were analyzed. Overall patient survival rates were 99.8%, 98.8%, and 91.8% at 1, 3, and 5 years, respectively. Death-censored graft survival rates were 98.4%, 97.0%, and 95.8% at 1, 3, and 5 years. Biopsy-proven acute rejection free survival rates were 90.1%, 87.4%, and 87.03% at 1, 3, and 5 years. The top 3 dominant predictors for recipient mortality within 1 year were recipient cardiovascular disease history, deceased donor, and recipient age. The dominant predictors for death-censored graft loss within 1 year were acute rejection, deceased donor, and desensitization. The dominant predictors to acute rejection within 1 year were donor age, HLA mismatched numbers, and desensitization. We presented clinical characteristics of patients enrolled in KOTRY during the last 5 years and investigated dominant predictors for early post-transplant outcomes, which would be useful for clinical decision-making based on quantitative measures.
Keimyung Author(s)(Kor)
한승엽
Publisher
School of Medicine (의과대학)
Citation
Jong Cheol Jeong et al. (2022). Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY). Sci Rep, 12, 8706. doi: 10.1038/s41598-022-12302-5
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-022-12302-5
DOI
10.1038/s41598-022-12302-5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44347
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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