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Stroke of Other Determined Etiology: Results From the Nationwide Multicenter Stroke Registry

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Author(s)
Hyunsoo KimJoon-Tae KimJi Sung LeeBeom Joon KimJihoon KangKeon-Joo LeeJong-Moo ParkKyusik KangSoo Joo LeeJae Guk KimJae-Kwan ChaDae-Hyun KimTai Hwan ParkKyung Bok LeeJun LeeKeun-Sik HongYong-Jin ChoHong-Kyun ParkByung-Chul LeeKyung-Ho YuMi Sun OhDong-Eog KimWi-Sun RyuJay Chol ChoiJee-Hyun KwonWook-Joo KimDong-Ick ShinKyu Sun YumSung Il SohnJeong-Ho HongSang-Hwa LeeMan-Seok ParkKang-Ho ChoiJuneyoung LeeHee-Joon Bae
Keimyung Author(s)
Sohn, Sung IlHong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
Stroke
Issued Date
2022
Volume
53
Issue
8
Keyword
dissectiondemographysyndromemigrainehemostatic
Abstract
Background:
Stroke of other determined etiology (OE) includes patients with an uncommon cause of stroke. We described the general characteristics, management, and outcomes of stroke in OE and its subgroups.

Methods:
This study is a retrospective analysis of a prospective, multicenter, nationwide registry, the Clinical Research Center for Stroke-Korea-National Institutes of Health registry. We classified OE strokes into 10 subgroups according to the literature and their properties. Each OE subgroup was compared according to clinical characteristics, sex, age strata, lesion locations, and management. Moreover, 1-year composites of stroke and all-cause mortality were investigated according to the OE subgroups.

Results:
In total, 2119 patients with ischemic stroke with OE types (mean age, 55.6±16.2 years; male, 58%) were analyzed. In the Clinical Research Center for Stroke-Korea-National Institutes of Health registry, patients with OE accounted for 2.8% of all patients with stroke. The most common subtypes were arterial dissection (39.1%), cancer-related coagulopathy (17.3%), and intrinsic diseases of the arterial wall (16.7%). Overall, strokes of OE were more common in men than in women (58% versus 42%). Arterial dissection, intrinsic diseases of the arterial wall and stroke associated with migraine and drugs were more likely to occur at a young age, while disorders of platelets and the hemostatic system, cancer-related coagulopathy, infectious diseases, and hypoperfusion syndromes were more frequent at an old age. The composite of stroke and all-cause mortality within 1 year most frequently occurred in cancer-related coagulopathy, with an event rate of 71.8%, but least frequently occurred in stroke associated with migraine and drugs and arterial dissection, with event rates of 0% and 7.2%, respectively.

Conclusions:
This study presents the different characteristics, demographic findings, lesion locations, and outcomes of OE and its subtypes. It is characterized by a high proportion of arterial dissection, high mortality risk in cancer-related coagulopathy and an increasing annual frequency of cancer-related coagulopathy in patients with stroke of OE.
Keimyung Author(s)(Kor)
손성일
홍정호
Publisher
School of Medicine (의과대학)
Citation
Hyunsoo Kim et al. (2022). Stroke of Other Determined Etiology: Results From the Nationwide Multicenter Stroke Registry. Stroke, 53(8), 2597–2606. doi: 10.1161/STROKEAHA.121.037582
Type
Article
ISSN
1524-4628
Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.037582
DOI
10.1161/STROKEAHA.121.037582
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44349
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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