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Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study

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Author(s)
Hee-Yeon JungYena JeonKyu Ha HuhJae Berm ParkMyung-Gyu KimSik LeeSeungyeup HanHan RoJaeseok YangCurie AhnJang-Hee ChoSun-Hee ParkYong-Lim KimChan-Duck Kim
Keimyung Author(s)
Han, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Transpl Int
Issued Date
2022
Volume
35
Keyword
kidney transplantationalcoholall-cause mortalitybiopsy-proven acute rejectioncardiovascular eventsdeath-censored graft failurelow-density lipoprotein cholesteroltotal cholesterol
Abstract
The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo, or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol (p < 0.001) and low-density lipoprotein cholesterol levels (p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels (p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile.
Keimyung Author(s)(Kor)
한승엽
Publisher
School of Medicine (의과대학)
Citation
Hee-Yeon Jung et al. (2022). Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study. Transpl Int, 35, 10243. doi: 10.3389/ti.2022.10243
Type
Article
ISSN
1432-2277
Source
https://www.frontierspartnerships.org/articles/10.3389/ti.2022.10243/full
DOI
10.3389/ti.2022.10243
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44350
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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