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Mendelian randomization reveals causal effects of kidney function on various biochemical parameters

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Author(s)
Sehoon ParkSoojin LeeYaerim KimSemin ChoHyeok HuhKwangsoo KimYong Chul KimSeung Seok HanHajeong LeeJung Pyo LeeKwon Wook JooChun Soo LimYon Su KimDong Ki Kim
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
Commun Biol
Issued Date
2022
Volume
5
Issue
1
Abstract
The kidney is a vital organ with diverse biological effects and the burden of kidney function impairment is increasing in modern medicine. As the effects from kidney function on diverse biochemical parameters are yet fully understood, additional investigation to reveal the causal effects is warranted. Here we show the causal estimates from kidney function parameter, estimated glomerular filtration rate (eGFR), on 60 biochemical parameters by performing two-sample Mendelian randomization (MR) study in 337,138 white British UK Biobank participants. A higher genetically predicted eGFR was significantly associated with higher lymphocyte percentage, HDL cholesterol, and alanine aminotransferase. The causal estimates indicated that a higher genetically predicted eGFR was associated with lower urea, urate, insulin growth factor-1, and triglycerides levels. The parameters with significant but non-linear causal estimates were hemoglobin concentration, calcium, vitamin D, and urine creatinine values, identified by non-linear MR. Healthcare providers should understand that changes in eGFR may affect the identified biochemical parameters in diverse patterns. Future study is warranted to expand the knowledge of the mechanisms and clinical implications of the causal effects of eGFR on various biochemical parameters.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2399-3642
Source
https://www.nature.com/articles/s42003-022-03659-4
DOI
10.1038/s42003-022-03659-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44366
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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