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Multidimensional Approach of Heart Failure Diagnosis and Prognostication Utilizing Cardiac Imaging with Biomarkers

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Author(s)
In-Cheol KimByung-Su Yoo
Keimyung Author(s)
Kim, In Cheol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diagnostics (Basel)
Issued Date
2022
Volume
12
Issue
6
Keyword
heart failurediagnosisprognosismultimodality imagingbiomarkers
Abstract
Heart failure (HF) is a clinical syndrome caused by various etiologies that results in systolic and diastolic cardiac dysfunction with congestion. While evaluating HF and planning for treatment, physicians utilize various laboratory tests, including electrocardiography, diverse imaging tests, exercise testing, invasive hemodynamic evaluation, or endomyocardial biopsy. Among these, cardiac imaging modalities and biomarkers are the mainstays during HF diagnosis and treatment. Recent developments in non-invasive imaging modalities, such as echocardiography, computed tomography, magnetic resonance imaging, and nuclear imaging, have helped us understand the etiology, pathophysiology, and hemodynamics of HF, and determine treatment options and predict the outcomes. Due to the convenience of their use and potential impact on HF management, biomarkers are increasingly adopted in our clinical practice as well as research purpose. Natriuretic peptide is the most widely used biomarker for the diagnosis of HF, evaluation of treatment response, and prediction of future outcomes. Other cardiac biomarkers to evaluate the pathophysiological mechanisms of HF include myocardial injury, oxidative stress, inflammation, fibrosis, hypertrophy, and neurohormonal activation. Because HF results from complex cardiac disorders, it is essential to assess the disease status multidimensionally. The proper utilization of multimodality imaging and cardiac biomarkers can improve the quality of patient management and predict clinical outcomes in HF in the era of personalized medicine.
Keimyung Author(s)(Kor)
김인철
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2075-4418
Source
https://www.mdpi.com/2075-4418/12/6/1366
DOI
10.3390/diagnostics12061366
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44369
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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