계명대학교 의학도서관 Repository

Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure

Metadata Downloads
Author(s)
Hyun Jung HongKyong Hye JoungYong Kyung KimMin Jeong ChoiSeul Gi KangJung Tae KimYea Eun KangJoon Young ChangJoon Ho MoonSangmi JunHyun-Joo RoYujeong LeeHyeongseok KimJae-Hyung ParkBaeki E. KangYunju JoHeejung ChoiDongryeol RyuChul-Ho LeeHail KimKyu-Sang ParkHyun Jin KimMinho Shong
Keimyung Author(s)
Park, Jae Hyung
Department
Dept. of Physiology (생리학)
Journal Title
Exp Mol Med
Issued Date
2022
Volume
54
Abstract
Genetic variations in mitoribosomal subunits and mitochondrial transcription factors are related to type 2 diabetes. However, the role of islet mitoribosomes in the development of type 2 diabetes has not been determined. We investigated the effects of the mitoribosomal gene on β-cell function and glucose homeostasis. Mitoribosomal gene expression was analyzed in datasets from the NCBI GEO website (GSE25724, GSE76894, and GSE76895) and the European Nucleotide Archive (ERP017126), which contain the transcriptomes of type 2 diabetic and nondiabetic organ donors. We found deregulation of most mitoribosomal genes in islets from individuals with type 2 diabetes, including partial downregulation of CRIF1. The phenotypes of haploinsufficiency in a single mitoribosomal gene were examined using β-cell-specific Crif1 (Mrpl59) heterozygous-deficient mice. Crif1beta+/− mice had normal glucose tolerance, but their islets showed a loss of first-phase glucose-stimulated insulin secretion. They also showed increased β-cell mass associated with higher expression of Reg family genes. However, Crif1beta+/− mice showed earlier islet failure in response to high-fat feeding, which was exacerbated by aging. Haploinsufficiency of a single mitoribosomal gene predisposes rodents to glucose intolerance, which resembles the early stages of type 2 diabetes in humans.
Keimyung Author(s)(Kor)
박재형
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2092-6413
Source
https://www.nature.com/articles/s12276-022-00797-x
DOI
10.1038/s12276-022-00797-x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44373
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.