계명대학교 의학도서관 Repository

Targeting Cancer Stem Cells: Therapeutic and diagnostic strategies by the virtue of nanoparticles

Metadata Downloads
Author(s)
Samjhana ShresthaAsmita BanstolaJee-Heon JeongJi Hae SeoSimmyung Yook
Keimyung Author(s)
Dept. of Biochemistry (생화학)
Department
Dept. of Biochemistry (생화학)
Journal Title
J Control Release
Issued Date
2022
Volume
348
Keyword
Cancer stem cellsTargeted therapyNanoparticlesBiomarkersDiagnosisTreatment
Abstract
Cancer stem cells (CSCs) are the subpopulation of cells present within a tumor with the properties of self-renewing, differentiating, and proliferating. Owing to the presence of ATP-binding cassette drug pumps and increased expression of anti-apoptotic proteins, the conventional chemotherapeutic agents have failed to eliminate CSCs resulting in relapse and resistance of cancer. Therefore, to obtain long-lasting clinical responses and avoid the recurrence of cancer, it is crucial to develop an efficient strategy targeting CSCs by either employing a differentiation therapy or specifically delivering drugs to CSCs. Several intracellular and extracellular cancer specific biomarkers are overexpressed by CSCs and are utilized as targets for the development of new approaches in the diagnosis and treatment of CSCs. Moreover, several nanostructured particles, alone or in combination with current treatment approaches, have been used to improve the detection, imaging, and targeting of CSCs, thus addressing the limitations of cancer therapies. Targeting CSC surface markers, stemness-related signaling pathways, and tumor microenvironmental signals has improved the detection and eradication of CSCs and, therefore, tumor diagnosis and treatment. This review summarizes a variety of promising nanoparticles targeting the surface biomarkers of CSCs for the detection and eradication of tumor-initiating stem cells, used in combination with other treatment regimens.
Keimyung Author(s)(Kor)
서지혜
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
0168-3659
Source
https://www.sciencedirect.com/science/article/abs/pii/S016836592200342X
DOI
10.1016/j.jconrel.2022.06.013
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44388
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.